DegronMD

Uniprot ID: A6H8Y1

Source protein: Transcription factor TFIIIB component B'' homolog

Source gene: BDP1

Class: DEG_SCF_FBW7_2

Location: 1362:1369

E3 ligase: FBXW7

DEGRON score: 0.8103

ASA_SCORE: 107.075

COIL: 0.7373

CONS_SCORE: 0.3554

DSS_SCORE: 0.5572

HELIX: 0.0753

FCONS_SCORE: 1.143

RIG_SCORE: 0.7233

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1374Q	TCGA-66-2773	LUSC	TCGA	MMHTPVEE	DEG_SCF_FBW7_2	0.1944
p.E1374Q	DO26536	LUSC	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	0.1944
p.K1375R	TCGA-CJ-4636	KIRC	TCGA	MMHTPVEE	DEG_SCF_FBW7_2	0.2778
p.K1375R	DO19298	KIRC	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	0.2778
p.E1374K	TCGA-E5-A4U1	BLCA	TCGA	MMHTPVEE	DEG_SCF_FBW7_2	0.1944
p.E1374K	DO44061	BLCA	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	0.1944
p.R1371I	TCGA-F5-6814	READ	TCGA	MMHTPVEE	DEG_SCF_FBW7_2	0.2778
p.R1371I	DO36556	READ	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	0.2778
p.E1368Q	TCGA-IR-A3LA	CESC	TCGA	MMHTPVEE	DEG_SCF_FBW7_2	0.5633
p.E1368Q	DO44377	CESC	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	0.5633
p.S1378L	DO231782	LINC	ICGC	MMHTPVEE	DEG_SCF_FBW7_2	0.0833
p.E1358D	SIDM00600	Thyroid Gland Carcinoma	GDSC	MMHTPVEE	DEG_SCF_FBW7_2	0.2222
p.E1358D	SIDM01451	Pancreatic Carcinoma	GDSC	MMHTPVEE	DEG_SCF_FBW7_2	0.2222
p.E1358D	IHH-4	thyroid	COSMIC	MMHTPVEE	DEG_SCF_FBW7_2	0.2222
p.S1357R	SIDM00508	Squamous Cell Lung Carcinoma	GDSC	MMHTPVEE	DEG_SCF_FBW7_2	0.1944
p.S1357R	ACH-001489	Lung Cancer	CCLE	MMHTPVEE	DEG_SCF_FBW7_2	0.1944
p.S1357R	COR-L32	lung	COSMIC	MMHTPVEE	DEG_SCF_FBW7_2	0.1944
p.V1367A	SIDM01588	Endometrial Carcinoma	GDSC	MMHTPVEE	DEG_SCF_FBW7_2	0.5825
p.V1367A	ACH-000993	Endometrial/Uterine Cancer	CCLE	MMHTPVEE	DEG_SCF_FBW7_2	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SCF_FBW7_2	1362:1369	MMHTPVEE	FBXW7	0.8103	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons