DegronMD

Uniprot ID: A6H8Y1

Source protein: Transcription factor TFIIIB component B'' homolog

Source gene: BDP1

Class: DEG_SCF_FBW7_1

Location: 212:218

E3 ligase: FBXW7

DEGRON score: 0.9338

ASA_SCORE: 97.9286

COIL: 0.953

CONS_SCORE: 0.3646

DSS_SCORE: 0.8197

HELIX: 0.0234

FCONS_SCORE: 0.8465

RIG_SCORE: 0.5984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P215A	TCGA-05-4250	LUAD	TCGA	PSTPVQT	DEG_SCF_FBW7_1	0.7503
p.E206A	TCGA-2W-A8YY	CESC	TCGA	PSTPVQT	DEG_SCF_FBW7_1	0.1667
p.E206A	DO223732	CESC	ICGC	PSTPVQT	DEG_SCF_FBW7_1	0.1667
p.V216D	TCGA-AJ-A3EK	UCEC	TCGA	PSTPVQT	DEG_SCF_FBW7_1	0.6674
p.V216D	DO41584	UCEC	ICGC	PSTPVQT	DEG_SCF_FBW7_1	0.6674
p.T222A	DO234424	ESAD	ICGC	PSTPVQT	DEG_SCF_FBW7_1	0.2222
p.I223L	DO22237	LGG	ICGC	PSTPVQT	DEG_SCF_FBW7_1	0.1944
p.R203S	DO24646	LUAD	ICGC	PSTPVQT	DEG_SCF_FBW7_1	0.0833
p.S224F	DO41235	UCEC	ICGC	PSTPVQT	DEG_SCF_FBW7_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SCF_FBW7_1	212:218	PSTPVQT	FBXW7	0.9338	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons