DegronMD

Uniprot ID: A6H8Y1

Source protein: Transcription factor TFIIIB component B'' homolog

Source gene: BDP1

Class: DEG_SPOP_SBC_1

Location: 2046:2050

E3 ligase: SPOP

DEGRON score: 0.9819

ASA_SCORE: 85.66

COIL: 0.7842

CONS_SCORE: 0.4476

DSS_SCORE: 0.4746

HELIX: 0.0116

FCONS_SCORE: 0.9625

RIG_SCORE: 0.7213

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S2050C	TCGA-DR-A0ZM	CESC	TCGA	VITTS	DEG_SPOP_SBC_1	0.8652
p.S2044L	SIDM00926	Non-Small Cell Lung Carcinoma	GDSC	VITTS	DEG_SPOP_SBC_1	0.7222
p.S2044L	ACH-000924	Lung Cancer	CCLE	VITTS	DEG_SPOP_SBC_1	0.7222
p.S2044L	NCI-H2172	lung	COSMIC	VITTS	DEG_SPOP_SBC_1	0.7222
p.S2043F	TCGA-Z2-A8RT	SKCM	TCGA	VITTS	DEG_SPOP_SBC_1	0.25
p.E2056K	SIDM01052	Ovarian Carcinoma	GDSC	VITTS	DEG_SPOP_SBC_1	0.1667
p.E2056K	ACH-000308	Ovarian Cancer	CCLE	VITTS	DEG_SPOP_SBC_1	0.1667
p.E2056K	EFO-21	ovary	COSMIC	VITTS	DEG_SPOP_SBC_1	0.1667

Showing 1 to 8 of 8 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	2046:2050	VITTS	SPOP	0.9819	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons