DegronMD

Uniprot ID: A6H8Y1

Source protein: Transcription factor TFIIIB component B'' homolog

Source gene: BDP1

Class: DEG_APCC_KENBOX_2

Location: 2076:2080

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9632

ASA_SCORE: 111.3

COIL: 0.72

CONS_SCORE: 0.3904

DSS_SCORE: 0.5187

HELIX: 0.2212

FCONS_SCORE: 1.0612

RIG_SCORE: 0.7177

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R2067S	TCGA-64-1680	LUAD	TCGA	VKENA	DEG_APCC_KENBOX_2	0.0833
p.S2088F	TCGA-A5-A0G2	UCEC	TCGA	VKENA	DEG_APCC_KENBOX_2	0.1111
p.I2087L	TCGA-DU-6392	LGG	TCGA	VKENA	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_APCC_KENBOX_2	2076:2080	VKENA	APC,CDC20,FZR1	0.9632	More...
Q9NYB0	Telomeric repeat-binding factor 2-interacting protein 1	DEG_APCC_KENBOX_2	148:152	VKENA	APC,CDC20,FZR1	0.6866	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons