DegronMD

Uniprot ID: A6H8Y1

Source protein: Transcription factor TFIIIB component B'' homolog

Source gene: BDP1

Class: DEG_SPOP_SBC_1

Location: 198:202

E3 ligase: SPOP

DEGRON score: 0.9993

ASA_SCORE: 76.96

COIL: 0.8326

CONS_SCORE: 0.5884

DSS_SCORE: 0.6236

HELIX: 0.1272

FCONS_SCORE: 1.0989

RIG_SCORE: 0.6384

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E206A	TCGA-2W-A8YY	CESC	TCGA	PMTSS	DEG_SPOP_SBC_1	0.2222
p.E206A	DO223732	CESC	ICGC	PMTSS	DEG_SPOP_SBC_1	0.2222
p.M199R	TCGA-85-8071	LUSC	TCGA	PMTSS	DEG_SPOP_SBC_1	0.7521
p.M199R	DO26755	LUSC	ICGC	PMTSS	DEG_SPOP_SBC_1	0.7521
p.E198Q	DO224650	BRCA	ICGC	PMTSS	DEG_SPOP_SBC_1	0.6744
p.I195V	DO230323	COCA	ICGC	PMTSS	DEG_SPOP_SBC_1	0.25
p.P194S	DO11854	GBM	ICGC	PMTSS	DEG_SPOP_SBC_1	0.2222
p.R203S	DO24646	LUAD	ICGC	PMTSS	DEG_SPOP_SBC_1	0.3056
p.E198K	DO232761	PBCA	ICGC	PMTSS	DEG_SPOP_SBC_1	0.7022
p.A188T	DO229275	THCA	ICGC	PMTSS	DEG_SPOP_SBC_1	0.0556
p.L197F	DO229232	THCA	ICGC	PMTSS	DEG_SPOP_SBC_1	0.3056
p.M199T	SIDM01608	Endometrial Carcinoma	GDSC	PMTSS	DEG_SPOP_SBC_1	0.6312
p.M199T	ACH-000990	Endometrial/Uterine Cancer	CCLE	PMTSS	DEG_SPOP_SBC_1	0.6312

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A6H8Y1	Transcription factor TFIIIB component B'' homolog	DEG_SPOP_SBC_1	198:202	PMTSS	SPOP	0.9993	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	411:415	PMTSS	SPOP	0.9969	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons