DegronMD - O60732(MAGEC1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T838S	TCGA-12-0829	GBM	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.6005
p.T838S	DO11166	GBM	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.6005
p.E296D	TCGA-17-Z003	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0556
p.S168R	TCGA-17-Z010	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.3056
p.S168R	TCGA-3N-A9WD	SKCM	TCGA	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.3056
p.S168R	DO51235	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.3056
p.S243Y	TCGA-17-Z062	LUAD	TCGA	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.712
p.E848G	TCGA-18-3409	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0833
p.E848G	DO26444	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0833
p.S823L	TCGA-19-5956	GBM	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.3056
p.S823L	DO13863	GBM	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.3056
p.F416V	TCGA-2W-A8YY	CESC	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.3056
p.F416V	DO223732	CESC	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.3056
p.Q460K	TCGA-33-AASI	LUSC	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0556
p.Q460K	DO219129	LUSC	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0556
p.E471V	TCGA-3X-AAV9	CHOL	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0556
p.Q409H	TCGA-44-5644	LUAD	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2778
p.Q409H	DO25153	LUAD	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2778
p.G472C	TCGA-49-AARE	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0833
p.G472C	DO218922	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0833
p.P813L	TCGA-50-5932	LUAD	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.1944
p.P813L	DO23610	LUAD	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.1944
p.S173Y	TCGA-55-7725	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.712
p.S173Y	DO24636	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.712
p.E401D	TCGA-55-8089	LUAD	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0556
p.E401D	TCGA-56-7730	LUSC	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0556
p.E401D	DO23690	LUAD	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0556
p.E401D	DO26617	LUSC	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0556
p.L421F	TCGA-56-7731	LUSC	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1667
p.L421F	TCGA-FU-A23L	CESC	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1667
p.L421F	DO6278	CESC	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1667
p.L421F	DO45527	LUSC	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1667
p.S486Y	TCGA-56-7822	LUSC	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.3056
p.S486Y	DO26638	LUSC	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.3056
p.L825I	TCGA-56-A49D	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.25
p.L825I	TCGA-56-A49D	LUSC	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0556
p.L825I	DO45475	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.25
p.L825I	DO45475	LUSC	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0556
p.S171Y	TCGA-63-A5ML	LUSC	TCGA	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.712
p.S171Y	DO219151	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.712
p.P809A	TCGA-64-1677	LUAD	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.0833
p.P809A	DO23996	LUAD	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.0833
p.T490N	TCGA-67-6217	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1944
p.T490N	DO25877	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1944
p.L458V	TCGA-75-6207	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.L458V	DO26190	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.E296V	TCGA-78-7536	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0556
p.E296V	DO26414	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.0556
p.P439S	TCGA-90-A4ED	LUSC	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P439S	TCGA-D3-A3MU	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P439S	TCGA-D3-A8GI	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P439S	DO45482	LUSC	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P439S	DO50284	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P439S	DO47337	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.S489T	TCGA-A5-A0G1	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.2222
p.S489T	DO42472	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.2222
p.A229V	TCGA-AA-3818	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229V	TCGA-EE-A3J7	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229V	DO7792	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229V	DO48770	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229V	Mewo	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.P411T	TCGA-AA-A010	COAD	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7031
p.S301Y	TCGA-AA-A03F	COAD	TCGA	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation blocking phosphorylation signal	0.6389
p.S301Y	DO10558	COAD	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation blocking phosphorylation signal	0.6389
p.S484F	TCGA-AC-A23H	BRCA	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.7982
p.S484F	DO2401	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.7982
p.S824C	TCGA-AF-5654	READ	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.2778
p.S824C	DO36647	READ	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.2778
p.L456S	TCGA-AP-A0LM	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1667
p.L456S	DO43306	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1667
p.L494I	TCGA-AX-A05Z	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0833
p.L494I	DO40884	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0833
p.F817S	TCGA-AX-A1C9	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.3056
p.F817S	DO43098	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.3056
p.P166H	TCGA-AX-A2HC	UCEC	TCGA	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.P166H	DO41572	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.P166H	ACH-001558	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.L455V	TCGA-AX-A2HC	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.L455V	DO41572	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1944
p.S829Y	TCGA-AX-A2HC	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.1389
p.S829Y	TCGA-AX-A2HC	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1667
p.S829Y	DO41572	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.1389
p.S829Y	DO41572	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1667
p.L246Q	TCGA-BA-4076	HNSC	TCGA	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.L246Q	DO14502	HNSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.Q827K	TCGA-BF-A1Q0	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.1944
p.Q827K	TCGA-BF-A1Q0	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1111
p.Q827K	DO47374	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.1944
p.Q827K	DO47374	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1111
p.L491V	TCGA-BK-A6W3	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1667
p.L491V	DO50076	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1667
p.P813H	TCGA-BR-4280	STAD	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.1944
p.P813H	DO38663	STAD	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.1944
p.S840L	TCGA-CA-6717	COAD	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.3056
p.S840L	DO8264	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.3056
p.P818H	TCGA-CN-5360	HNSC	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation altering degron motif	0.7694
p.P818H	DO14662	HNSC	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation altering degron motif	0.7694
p.V831E	TCGA-CR-7398	HNSC	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.0833
p.V831E	TCGA-CR-7398	HNSC	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.2222
p.V831E	DO14782	HNSC	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.0833
p.V831E	DO14782	HNSC	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.2222
p.P442H	TCGA-D1-A16X	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.P442H	DO41799	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.S452F	TCGA-D3-A3C8	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.S452F	DO47636	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2778
p.P474S	TCGA-D3-A51T	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474S	TCGA-D3-A8GL	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474S	TCGA-EE-A29D	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474S	DO50287	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474S	DO47389	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474S	DO38123	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474S	SIDM00190	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474S	CP66-MEL	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P236L	TCGA-D3-A8GD	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.P236L	DO50282	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.S488F	TCGA-D3-A8GV	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.25
p.S488F	DO219477	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.25
p.P404S	TCGA-D9-A1JW	SKCM	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.P404S	TCGA-EE-A2GM	SKCM	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.P404S	TCGA-FW-A3R5	SKCM	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.P404S	DO220903	MELA	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.P404S	DO37555	SKCM	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.P404S	DO37786	SKCM	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.P404S	DO37406	SKCM	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.S822L	TCGA-DU-6401	LGG	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation altering degron motif	0.7667
p.S822L	DO22490	LGG	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation altering degron motif	0.7667
p.S836F	TCGA-EA-A3HU	CESC	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.6871
p.S836F	TCGA-RP-A694	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.6871
p.S836F	DO6320	CESC	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.6871
p.S836F	DO51269	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.6871
p.P411S	TCGA-EE-A2GH	SKCM	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.6752
p.P411S	DO37643	SKCM	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.6752
p.L456M	TCGA-EE-A2M5	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1667
p.L456M	DO37425	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1667
p.G472S	TCGA-EE-A3JD	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0833
p.G472S	DO50299	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0833
p.Q475L	TCGA-EM-A3SZ	THCA	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1667
p.Q475L	DO48129	THCA	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1667
p.S820F	TCGA-EO-A22U	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation altering degron motif	0.7982
p.S820F	DO43755	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation altering degron motif	0.7982
p.Q304K	TCGA-ER-A2NB	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.Q304K	DO47448	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.P446S	TCGA-ER-A2ND	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6752
p.P446S	DO47449	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6752
p.P306H	TCGA-F5-6814	READ	TCGA	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7694
p.P306H	DO36556	READ	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7694
p.K844N	TCGA-FD-A6TF	BLCA	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation substituting flanking lysine	0.3056
p.K844N	DO51880	BLCA	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation substituting flanking lysine	0.3056
p.S849R	TCGA-FI-A2F4	UCEC	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0556
p.S849R	DO43434	UCEC	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0556
p.P477S	TCGA-FR-A3YO	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.2222
p.P477S	DO37419	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.2222
p.P439L	TCGA-FR-A8YE	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P439L	DO50303	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P439L	SIDM01175	Other Sarcomas	GDSC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P439L	ACH-002309	Sarcoma	CCLE	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.P439L	SW684	soft tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1389
p.S313F	TCGA-FS-A1Z3	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.S313F	TCGA-QQ-A5VD	SARC	TCGA	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.S313F	DO220252	SARC	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.S313F	DO37635	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.S476F	TCGA-FS-A1ZD	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1944
p.S476F	DO37627	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1944
p.F834L	TCGA-G4-6320	COAD	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.3056
p.F834L	DO8159	COAD	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.3056
p.S846F	TCGA-GN-A26A	SKCM	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1389
p.S846F	DO37861	SKCM	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1389
p.V447G	TCGA-HF-7136	STAD	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6421
p.V447G	DO38226	STAD	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6421
p.V447G	SIDM01451	Pancreatic Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6421
p.V447G	SIDM00678	Bladder Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6421
p.V447G	SIDM00282	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6421
p.V447G	SIDM00379	Glioma	GDSC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6421
p.V447G	SIDM01336	Glioblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6421
p.V447G	HT-1376	urinary tract	COSMIC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6421
p.V447G	CW-2	large intestine	COSMIC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.6421
p.S450C	TCGA-IR-A3LH	CESC	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7541
p.S450C	DO44381	CESC	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7541
p.P166L	TCGA-L9-A7SV	LUAD	TCGA	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.P166L	DO49875	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.L458I	TCGA-ND-A4WC	UCS	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.L458I	DO232445	PBCA	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.L458I	SIDM00798	Rhabdomyosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.L458I	SIDM01101	Neuroblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1111
p.Y453C	TCGA-OR-A5LB	ACC	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.I423L	TCGA-P3-A6T7	HNSC	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1111
p.I423L	TCGA-YL-A8SO	PRAD	TCGA	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1111
p.I423L	DO49033	HNSC	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1111
p.I423L	DO51436	PRAD	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1111
p.S487F	TCGA-P3-A6T7	HNSC	TCGA	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.2778
p.S487F	DO49033	HNSC	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.2778
p.S168C	TCGA-QK-A8Z8	HNSC	TCGA	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.3056
p.S168C	DO52097	HNSC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.3056
p.Q300K	TCGA-V5-A7RC	ESCA	TCGA	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1667
p.P847T	TCGA-W5-AA2U	CHOL	TCGA	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1111
p.P446L	TCGA-XE-AAO4	TGCT	TCGA	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation altering degron motif	0.7582
p.L248I	DO48434	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1944
p.L248I	DO222829	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1944
p.L248I	DO223106	ESCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1944
p.L248I	DO52381	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1944
p.F179L	DO225249	BRCA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1667
p.F179L	SIDM00278	Esophageal Squamous Cell Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1667
p.F179L	ACH-000305	Esophageal Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1667
p.F179L	EC-GI-10	oesophagus	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1667
p.V307M	DO4138	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01518	Oral Cavity Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01137	Pancreatic Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01070	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01722	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00174	Head and Neck Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01090	Colorectal Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00602	Gastric Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00697	Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00795	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00908	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00180	Kidney Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01026	Esophageal Squamous Cell Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01011	B-Cell Non-Hodgkin's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00505	Pancreatic Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01063	Acute Myeloid Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00968	Ovarian Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00629	Breast Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00685	Glioblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01645	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00380	Acute Myeloid Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00196	Ewing's Sarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00743	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01205	Acute Myeloid Leukemia	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00123	Kidney Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM00303	Ovarian Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.V307M	SIDM01761	Rhabdomyosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6097
p.P442S	DO229361	BTCA	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.S168T	DO9330	COAD	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.3056
p.S309P	DO224685	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7863
p.S309P	DO222774	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7863
p.S309P	DO229232	THCA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7863
p.A229P	DO224761	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229P	DO229505	LAML	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229P	DO228941	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229P	DO228942	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229P	DO229012	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229P	DO229060	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229P	DO229006	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.A229P	DO52387	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.S241F	DO224731	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7982
p.S241F	DO222829	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7982
p.S241F	DO229010	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7982
p.S241F	DO229016	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7982
p.S241F	DO225404	LAML	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7982
p.S241F	DO230539	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7982
p.S241F	DO52346	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7982
p.S253P	DO222560	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.S253P	DO222793	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.S253P	DO222829	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.S253P	DO52376	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.S253P	DO52365	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.S253P	DO52343	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.P302S	DO222741	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2222
p.P299A	DO222741	COCA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.P299A	DO218872	SKCA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.F252S	DO222793	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0833
p.F252S	DO52376	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0833
p.F252S	DO52365	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0833
p.I178L	DO222733	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.I178L	DO222891	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.I178L	DO222804	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.I178L	DO51007	LAML	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.I178L	DO228947	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.I178L	DO229019	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.I178L	DO52367	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.I178L	DO52381	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.P411H	DO222874	COCA	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation altering degron motif	0.7694
p.V176L	DO222804	COCA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	DO228947	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	DO229047	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	DO229052	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	DO229006	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	DO52367	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	DO229499	SKCA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	SIDM00388	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	SIDM00143	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	SIDM00406	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	SIDM00793	Burkitt's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	SIDM01435	Hepatocellular Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	SIDM01605	Non-Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	SIDM01691	Chronic Myelogenous Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	COLO-668	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	SU-DHL-5	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.V176L	EB-3	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.P239R	DO222829	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7512
p.P239R	DO228903	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7512
p.L246V	DO222856	COCA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.L246V	DO51492	PACA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.P407T	DO222441	ESCA	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.2222
p.P809L	DO233115	GACA	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.0833
p.S242F	DO233663	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7982
p.S312F	DO233663	GACA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2778
p.Y453S	DO229345	LAML	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.Y453S	DO228902	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.Y453S	DO228976	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.Y453S	DO228891	MALY	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.Y453S	NCI-H1105	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.25
p.V162L	DO50994	LAML	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1389
p.V162L	DO227531	PACA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1389
p.V162A	DO50994	LAML	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1389
p.V162A	DO227531	PACA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1389
p.V162I	DO22706	LGG	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1389
p.V162I	DO50140	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1389
p.V162I	DO41542	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1389
p.A183D	DO231965	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.0556
p.Q234R	DO228941	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1944
p.P232S	DO228941	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.P232S	DO23508	LIRI	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.P232S	DO231075	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.G437C	DO228942	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.0833
p.P239S	DO228947	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.6752
p.P239S	DO229047	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.6752
p.P239S	DO229006	LICA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.6752
p.P239S	DO52365	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.6752
p.P239S	DO52343	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.6752
p.P302L	DO229029	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.2222
p.S177I	DO229022	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2222
p.P835S	DO50756	LICA	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.6752
p.P442L	DO44792	LICA	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.A169T	DO44832	LICA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7139
p.A169T	SIDM01151	Hepatocellular Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7139
p.A169T	SNU-182	liver	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7139
p.A173D	DO45346	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7793
p.A183T	DO24890	LUAD	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.0556
p.P163T	DO219191	LUSC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1667
p.F817L	DO228338	MALY	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.3056
p.F817L	ACH-002232	Lymphoma	CCLE	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.3056
p.F817L	DG-75	haematopoietic and lymphoid tissue	COSMIC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.3056
p.P236S	DO220877	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.25
p.F495Y	DO220877	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0556
p.F817Y	DO220877	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.3056
p.L163F	DO220877	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1667
p.P299S	DO222363	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.P299S	MEL-HO	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.P167S	DO222491	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.P167S	DO51249	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2778
p.S816F	DO222542	MELA	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.2778
p.P159S	DO222644	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.0556
p.P232L	DO222694	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.P183S	DO222847	MELA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.0556
p.I164T	DO34136	PACA	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.S311F	DO35558	PBCA	ICGC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.3056
p.L825V	DO232736	PBCA	ICGC	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.25
p.L825V	DO232736	PBCA	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.0556
p.S486F	DO232445	PBCA	ICGC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.3056
p.K159N	DO36385	READ	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.0556
p.K159N	DO41903	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.0556
p.K159N	DO42713	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.0556
p.K159N	DO41379	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.0556
p.F166I	DO37130	READ	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.F451S	DO46949	RECA	ICGC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.F451S	NCI-H1105	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.3056
p.G402D	DO229453	SKCA	ICGC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.0833
p.S839L	DO229456	SKCA	ICGC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation altering degron motif	0.7667
p.D176N	DO47265	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.D172N	DO37814	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.6932
p.D172N	NCI-H929	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.6932
p.D172N	NCI-H446	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.6932
p.S169F	DO51301	SKCM	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7982
p.A173T	DO48032	STAD	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7139
p.A183V	DO41542	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.0556
p.A181V	DO42400	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1111
p.Y170C	DO42713	UCEC	ICGC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7087
p.K844M	SIDM02070	Esophageal Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation substituting flanking lysine	0.3056
p.S313Y	SIDM01295	Pancreatic Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.V482G	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.6421
p.V482G	KYSE-140	oesophagus	COSMIC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.6421
p.V482G	LU-139	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.6421
p.S484P	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.6752
p.S484P	SIDM00411	Pancreatic Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.6752
p.S484P	SIDM00861	Ovarian Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.6752
p.S484P	SIDM00165	Other Solid Cancers	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.6752
p.S484P	SIDM00158	Glioblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.6752
p.S484P	ES-2	ovary	COSMIC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.6752
p.S484P	YAPC	pancreas	COSMIC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation altering degron motif	0.6752
p.P299L	SIDM00545	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.P299L	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.P299L	ACH-000875	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.P299L	ACH-000987	Skin Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.P299L	NCI-H2347	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.P299L	Mewo	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1389
p.L456V	SIDM00798	Rhabdomyosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.1667
p.P474A	SIDM00798	Rhabdomyosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474A	SIDM00806	Osteosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474A	SIDM01101	Neuroblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474A	SIDM00752	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.P474A	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.1389
p.L303P	SIDM00222	Mesothelioma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.L303P	ACH-000319	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.L303P	MPP-89	pleura	COSMIC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.25
p.P404A	SIDM00967	Ovarian Carcinoma	GDSC	PMTSS	DEG_SPOP_SBC_1	411:415	Mutation rewiring degron network	0.1389
p.T454I	SIDM00258	Neuroblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.T454I	ACH-002279	Neuroblastoma	CCLE	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.T454I	NB12	autonomic ganglia	COSMIC	PVSSS	DEG_SPOP_SBC_1	446:450	Mutation rewiring degron network	0.2222
p.S177N	SIDM00950	Pancreatic Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.2222
p.Q250K	SIDM00282	Colorectal Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.Q250K	ACH-000998	Colon/Colorectal Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.Q250K	CW-2	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.S171F	SIDM00796	Head and Neck Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7982
p.S171F	A253	salivary gland	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7982
p.Q164L	SIDM00710	Small Cell Lung Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.Q164L	ACH-000394	Lung Cancer	CCLE	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.Q164L	NCI-H2081	lung	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1944
p.S301C	SIDM00710	Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation blocking phosphorylation signal	0.6389
p.S301C	ACH-000394	Lung Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation blocking phosphorylation signal	0.6389
p.S301C	NCI-H2081	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation blocking phosphorylation signal	0.6389
p.P477A	SIDM00892	Breast Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.2222
p.P477A	ACH-000818	Breast Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.2222
p.P477A	BT-483	breast	COSMIC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.2222
p.L315S	SIDM00208	Glioblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1944
p.L315S	ACH-002229	Brain Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1944
p.L315S	D-502MG	central nervous system	COSMIC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation rewiring degron network	0.1944
p.E471Q	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0556
p.E471Q	A549	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.0556
p.A169P	SIDM00576	Acute Myeloid Leukemia	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.6392
p.A169P	NKM-1	haematopoietic and lymphoid tissue	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.6392
p.S171A	SIDM01609	Endometrial Carcinoma	GDSC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation altering degron motif	0.7588
p.S843P	SIDM01609	Endometrial Carcinoma	GDSC	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.2222
p.S843P	ACH-000972	Endometrial/Uterine Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.2222
p.S812C	ACH-000455	Brain Cancer	CCLE	PSSTS	DEG_SPOP_SBC_1	818:822	Mutation rewiring degron network	0.1667
p.S846Y	ACH-001148	Lymphoma	CCLE	PSSTS	DEG_SPOP_SBC_1	835:839	Mutation rewiring degron network	0.1389
p.D176V	Mewo	skin	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.25
p.S488T	MN-60	haematopoietic and lymphoid tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	481:485	Mutation rewiring degron network	0.25
p.V237G	LIM1215	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2778
p.V237G	JHOS-4	ovary	COSMIC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2778
p.V237G	CML-T1	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2778
p.S310F	Mewo	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.7982
p.V307G	KYSE-140	oesophagus	COSMIC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6421
p.V307G	LU-139	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	306:310	Mutation altering degron motif	0.6421
p.T161I	HCC1569	breast	COSMIC	AASSS	DEG_SPOP_SBC_1	169:173	Mutation rewiring degron network	0.1111
p.S240F	Mewo	skin	COSMIC	PSSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.6871

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MAGEC1

UniProt ID: O60732

Entrez ID: 9947

Protein name: Melanoma-associated antigen C1 (Cancer/testis antigen 7.1) (CT7.1) (MAGE-C1 antigen)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MAGEC1 in