DegronMD

Uniprot ID: O60732

Source protein: Melanoma-associated antigen C1

Source gene: MAGEC1

Class: DEG_SPOP_SBC_1

Location: 481:485

E3 ligase: SPOP

DEGRON score: 0.9669

ASA_SCORE: 87.6

COIL: 0.9672

CONS_SCORE: 0.4048

DSS_SCORE: 0.4178

HELIX: 0.0126

FCONS_SCORE: 0.9933

RIG_SCORE: 0.6422

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E471V	TCGA-3X-AAV9	CHOL	TCGA	PVSSS	DEG_SPOP_SBC_1	0.0556
p.G472C	TCGA-49-AARE	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	0.0833
p.G472C	DO218922	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.S486Y	TCGA-56-7822	LUSC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.3056
p.S486Y	DO26638	LUSC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.3056
p.T490N	TCGA-67-6217	LUAD	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1944
p.T490N	DO25877	LUAD	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1944
p.S489T	TCGA-A5-A0G1	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.2222
p.S489T	DO42472	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2222
p.S484F	TCGA-AC-A23H	BRCA	TCGA	PVSSS	DEG_SPOP_SBC_1	0.7982
p.S484F	DO2401	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.7982
p.L494I	TCGA-AX-A05Z	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.0833
p.L494I	DO40884	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.L491V	TCGA-BK-A6W3	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1667
p.L491V	DO50076	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1667
p.P474S	TCGA-D3-A51T	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474S	TCGA-D3-A8GL	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474S	TCGA-EE-A29D	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474S	DO50287	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474S	DO47389	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474S	DO38123	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474S	SIDM00190	Melanoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474S	CP66-MEL	skin	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.S488F	TCGA-D3-A8GV	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.25
p.S488F	DO219477	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.25
p.G472S	TCGA-EE-A3JD	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.0833
p.G472S	DO50299	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.0833
p.Q475L	TCGA-EM-A3SZ	THCA	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1667
p.Q475L	DO48129	THCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1667
p.P477S	TCGA-FR-A3YO	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.2222
p.P477S	DO37419	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2222
p.S476F	TCGA-FS-A1ZD	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	0.1944
p.S476F	DO37627	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	0.1944
p.S487F	TCGA-P3-A6T7	HNSC	TCGA	PVSSS	DEG_SPOP_SBC_1	0.2778
p.S487F	DO49033	HNSC	ICGC	PVSSS	DEG_SPOP_SBC_1	0.2778
p.F495Y	DO220877	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.0556
p.S486F	DO232445	PBCA	ICGC	PVSSS	DEG_SPOP_SBC_1	0.3056
p.V482G	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V482G	KYSE-140	oesophagus	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.V482G	LU-139	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6421
p.S484P	SIDM01764	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6752
p.S484P	SIDM00411	Pancreatic Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6752
p.S484P	SIDM00861	Ovarian Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6752
p.S484P	SIDM00165	Other Solid Cancers	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6752
p.S484P	SIDM00158	Glioblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.6752
p.S484P	ES-2	ovary	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6752
p.S484P	YAPC	pancreas	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.6752
p.P474A	SIDM00798	Rhabdomyosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474A	SIDM00806	Osteosarcoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474A	SIDM01101	Neuroblastoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474A	SIDM00752	Non-Cancerous	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P474A	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.1389
p.P477A	SIDM00892	Breast Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.2222
p.P477A	ACH-000818	Breast Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	0.2222
p.P477A	BT-483	breast	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.2222
p.E471Q	SIDM00903	Non-Small Cell Lung Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	0.0556
p.E471Q	A549	lung	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.0556
p.S488T	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O60381	HMG box-containing protein 1	DEG_SPOP_SBC_1	154:158	PVSSS	SPOP	0.9698	More...
O95628	CCR4-NOT transcription complex subunit 4	DEG_SPOP_SBC_1	380:384	PVSSS	SPOP	0.8257	More...
P07196	Neurofilament light polypeptide	DEG_SPOP_SBC_1	46:50	PVSSS	SPOP	0.8899	More...
P19793	Retinoic acid receptor RXR-alpha	DEG_SPOP_SBC_1	100:104	PVSSS	SPOP	0.9322	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	599:603	PVSSS	SPOP	0.9897	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	1234:1238	PVSSS	SPOP	0.8806	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	869:873	PVSSS	SPOP	0.7599	More...
P54259	Atrophin-1	DEG_SPOP_SBC_1	567:571	PVSSS	SPOP	0.8885	More...
P55197	Protein AF-10	DEG_SPOP_SBC_1	590:594	PVSSS	SPOP	0.8983	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1009:1013	PVSSS	SPOP	0.7108	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1582:1586	PVSSS	SPOP	0.9597	More...
Q14686	Nuclear receptor coactivator 6	DEG_SPOP_SBC_1	1810:1814	PVSSS	SPOP	0.9944	More...
Q15772	Striated muscle preferentially expressed protein kinase	DEG_SPOP_SBC_1	2893:2897	PVSSS	SPOP	0.9847	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	916:920	PVSSS	SPOP	0.9081	More...
Q5T6F2	Ubiquitin-associated protein 2	DEG_SPOP_SBC_1	631:635	PVSSS	SPOP	0.9929	More...
Q6AI39	BRD4-interacting chromatin-remodeling complex-associated protein-like	DEG_SPOP_SBC_1	588:592	PVSSS	SPOP	0.6309	More...
Q6ZN04	RNA-binding protein MEX3B	DEG_SPOP_SBC_1	391:395	PVSSS	SPOP	0.9174	More...
Q6ZNA4	E3 ubiquitin-protein ligase Arkadia	DEG_SPOP_SBC_1	593:597	PVSSS	SPOP	0.7583	More...
Q6ZP82	Coiled-coil domain-containing protein 141	DEG_SPOP_SBC_1	1237:1241	PVSSS	SPOP	0.926	More...
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like	DEG_SPOP_SBC_1	1586:1590	PVSSS	SPOP	0.8722	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	97:101	PVSSS	SPOP	0.8909	More...
Q8NDF8	Terminal nucleotidyltransferase 4B	DEG_SPOP_SBC_1	445:449	PVSSS	SPOP	0.9935	More...
Q8NEY1	Neuron navigator 1	DEG_SPOP_SBC_1	693:697	PVSSS	SPOP	0.9862	More...
Q92613	Protein Jade-3	DEG_SPOP_SBC_1	6:10	PVSSS	SPOP	0.9389	More...
Q92793	CREB-binding protein	DEG_SPOP_SBC_1	891:895	PVSSS	SPOP	0.9523	More...
Q9C0C6	CLOCK-interacting pacemaker	DEG_SPOP_SBC_1	245:249	PVSSS	SPOP	0.9936	More...
Q9NSI6	Bromodomain and WD repeat-containing protein 1	DEG_SPOP_SBC_1	1701:1705	PVSSS	SPOP	0.996	More...
Q9NY27	Serine/threonine-protein phosphatase 4 regulatory subunit 2	DEG_SPOP_SBC_1	369:373	PVSSS	SPOP	0.8095	More...
Q9UK61	Protein TASOR	DEG_SPOP_SBC_1	1122:1126	PVSSS	SPOP	0.992	More...
Q9ULM3	YEATS domain-containing protein 2	DEG_SPOP_SBC_1	977:981	PVSSS	SPOP	0.9676	More...
Q8TDY8	Immunoglobulin superfamily DCC subclass member 4	DEG_SPOP_SBC_1	1245:1249	PVSSS	SPOP	0.9694	More...
A0AUZ9	KAT8 regulatory NSL complex subunit 1-like protein	DEG_SPOP_SBC_1	208:212	PVSSS	SPOP	0.5228	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	306:310	PVSSS	SPOP	0.9847	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	446:450	PVSSS	SPOP	0.94	More...
O60732	Melanoma-associated antigen C1	DEG_SPOP_SBC_1	481:485	PVSSS	SPOP	0.9669	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	337:341	PVSSS	SPOP	0.9791	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVSSS

Degron related mutations and impact score

Drug responses associated with MAGEC1 mutations

All proteins holding degron of PVSSS