DegronMD - Q2NKQ1(SGSM1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G921S	TCGA-A5-A0GX	UCEC	TCGA	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.3056
p.G921S	TCGA-W3-AA1V	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.3056
p.G921S	DO51276	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.3056
p.G921S	DO41734	UCEC	ICGC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.3056
p.G756W	TCGA-AP-A056	UCEC	TCGA	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.0556
p.G756W	DO43971	UCEC	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.0556
p.H769Y	TCGA-D3-A51G	SKCM	TCGA	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation altering degron motif	0.6118
p.H769Y	DO47700	SKCM	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation altering degron motif	0.6118
p.G761S	TCGA-D5-6530	COAD	TCGA	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.1944
p.G761S	DO8312	COAD	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.1944
p.L779F	TCGA-EB-A51B	SKCM	TCGA	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.1389
p.L779F	DO47343	SKCM	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.1389
p.S919F	TCGA-EE-A29L	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation altering degron motif	0.7982
p.S918F	TCGA-EE-A3AA	SKCM	TCGA	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation altering degron motif	0.7982
p.S918F	DO37571	SKCM	ICGC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation altering degron motif	0.7982
p.A906T	TCGA-EY-A215	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7139
p.A906T	DO42665	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation altering degron motif	0.7139
p.S764F	TCGA-FW-A3R5	SKCM	TCGA	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.2778
p.S764F	DO37406	SKCM	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.2778
p.D930N	TCGA-HU-A4GU	STAD	TCGA	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.0556
p.E904K	DO447	BLCA	ICGC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.2778
p.L929V	DO3614	BRCA	ICGC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.0833
p.M926I	DO233791	GACA	ICGC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.1667
p.H917L	DO233740	GACA	ICGC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation altering degron motif	0.7313
p.D780N	DO229177	LMS	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.1111
p.P900S	DO25927	LUAD	ICGC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1667
p.S776F	DO222521	MELA	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.2222
p.S918L	DO222632	MELA	ICGC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation altering degron motif	0.7667
p.E913K	DO218874	SKCA	ICGC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.25
p.E913K	DO218874	SKCA	ICGC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.25
p.E774K	DO37444	SKCM	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.2778
p.Q768K	DO38011	SKCM	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation altering degron motif	0.6944
p.R773Q	DO41361	UCEC	ICGC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.3056
p.A911S	SIDM00422	Hodgkin's Lymphoma	GDSC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.A911S	SIDM00422	Hodgkin's Lymphoma	GDSC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.1944
p.A911S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.3056
p.A911S	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.1944
p.P770S	SIDM00007	Other Solid Cancers	GDSC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation altering degron motif	0.5641
p.P770S	MCC13	skin	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation altering degron motif	0.5641
p.S904F	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.2778
p.S904F	LK-2	lung	COSMIC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.2778
p.P900H	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1667
p.P900H	NCI-H1651	lung	COSMIC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1667
p.V922I	SIDM00213	Thyroid Gland Carcinoma	GDSC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.2778
p.V922I	FTC-133	thyroid	COSMIC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.2778
p.R773W	ACH-000190	Unknown	CCLE	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.3056
p.R773W	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.3056
p.V923A	ACH-000848	Liver Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.25
p.V923A	JHH-7	liver	COSMIC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.25
p.D757Y	ACH-000963	Colon/Colorectal Cancer	CCLE	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.0833
p.D757Y	CCK-81	large intestine	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.0833
p.E763K	ACH-002180	Cervical Cancer	CCLE	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.25
p.E763K	OMC-1	cervix	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.25
p.L929F	ACH-002249	Head and Neck Cancer	CCLE	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.0833
p.L929F	JHU-011	upper aerodigestive tract	COSMIC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.0833
p.A901T	ACH-002275	Leukemia	CCLE	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1944
p.A901T	MN-60	haematopoietic and lymphoid tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	906:910	Mutation rewiring degron network	0.1944
p.L923F	JHU-011	upper aerodigestive tract	COSMIC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation rewiring degron network	0.25
p.V917A	JHH-7	liver	COSMIC	PVSSS	DEG_SPOP_SBC_1	916:920	Mutation altering degron motif	0.5825
p.E757K	OMC-1	cervix	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation rewiring degron network	0.0833
p.R767W	HD-MY-Z	haematopoietic and lymphoid tissue	COSMIC	DSGHPSS	DEG_SCF_TRCP1_1	766:772	Mutation altering degron motif	0.8634

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SGSM1

UniProt ID: Q2NKQ1

Entrez ID: 129049

Protein name: Small G protein signaling modulator 1 (RUN and TBC1 domain-containing protein 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SGSM1 in