DegronMD

Uniprot ID: Q2NKQ1

Source protein: Small G protein signaling modulator 1

Source gene: SGSM1

Class: DEG_SPOP_SBC_1

Location: 906:910

E3 ligase: SPOP

DEGRON score: 0.9012

ASA_SCORE: 76.88

COIL: 0.7268

CONS_SCORE: 0.2159

DSS_SCORE: 0.3525

HELIX: 0.1726

FCONS_SCORE: 0.7859

RIG_SCORE: 0.7304

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A906T	TCGA-EY-A215	UCEC	TCGA	AVTTS	DEG_SPOP_SBC_1	0.7139
p.A906T	DO42665	UCEC	ICGC	AVTTS	DEG_SPOP_SBC_1	0.7139
p.E904K	DO447	BLCA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.2778
p.P900S	DO25927	LUAD	ICGC	AVTTS	DEG_SPOP_SBC_1	0.1667
p.E913K	DO218874	SKCA	ICGC	AVTTS	DEG_SPOP_SBC_1	0.25
p.A911S	SIDM00422	Hodgkin's Lymphoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.3056
p.A911S	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.3056
p.S904F	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.2778
p.S904F	LK-2	lung	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.2778
p.P900H	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	AVTTS	DEG_SPOP_SBC_1	0.1667
p.P900H	NCI-H1651	lung	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.1667
p.A901T	ACH-002275	Leukemia	CCLE	AVTTS	DEG_SPOP_SBC_1	0.1944
p.A901T	MN-60	haematopoietic_and_lymphoid_tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A4D1E9	GTP-binding protein 10	DEG_SPOP_SBC_1	378:382	AVTTS	SPOP	0.8328	More...
O15042	U2 snRNP-associated SURP motif-containing protein	DEG_SPOP_SBC_1	773:777	AVTTS	SPOP	0.9929	More...
O75376	Nuclear receptor corepressor 1	DEG_SPOP_SBC_1	2240:2244	AVTTS	SPOP	0.9879	More...
Q2NKQ1	Small G protein signaling modulator 1	DEG_SPOP_SBC_1	906:910	AVTTS	SPOP	0.9012	More...
Q86TC9	Myopalladin	DEG_SPOP_SBC_1	702:706	AVTTS	SPOP	0.7279	More...
Q8TEW8	Partitioning defective 3 homolog B	DEG_SPOP_SBC_1	616:620	AVTTS	SPOP	0.734	More...
Q9UKM9	RNA-binding protein Raly	DEG_SPOP_SBC_1	172:176	AVTTS	SPOP	0.9427	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	422:426	AVTTS	SPOP	0.8621	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons