DegronMD - Q9H0E3(SAP130)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G396V	TCGA-06-1084	GBM	TCGA	APTST	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.1389
p.P506L	TCGA-3L-AA1B	COAD	TCGA	PITSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.7582
p.T305M	TCGA-46-3768	LUSC	TCGA	VITTT	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7423
p.T305M	TCGA-BR-6452	STAD	TCGA	VITTT	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7423
p.T305M	TCGA-T2-A6WZ	HNSC	TCGA	VITTT	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7423
p.T305M	DO219067	HNSC	ICGC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7423
p.T305M	DO26466	LUSC	ICGC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7423
p.T305M	DO38404	STAD	ICGC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7423
p.H502Y	TCGA-94-8491	LUSC	TCGA	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.2222
p.P287T	TCGA-A5-A1OF	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.1944
p.R232Q	TCGA-AP-A056	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.R232Q	DO43971	UCEC	ICGC	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.Y497C	TCGA-BR-4361	STAD	TCGA	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.0833
p.E452K	TCGA-D5-5541	COAD	TCGA	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.591
p.A237V	TCGA-DI-A1BU	UCEC	TCGA	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2778
p.A237V	DO42023	UCEC	ICGC	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2778
p.I507M	TCGA-DK-A1A3	BLCA	TCGA	PITSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.6507
p.A307V	TCGA-DU-6392	LGG	TCGA	VITTT	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.3056
p.A307V	SIDM00999	Bladder Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.3056
p.A307V	639-V	urinary tract	COSMIC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.3056
p.Q743H	TCGA-E9-A1NC	BRCA	TCGA	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1944
p.G233C	TCGA-EE-A183	SKCM	TCGA	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1667
p.G233C	DO37715	SKCM	ICGC	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1667
p.P404L	TCGA-EE-A2GR	SKCM	TCGA	APTST	DEG_SPOP_SBC_1	403:407	Mutation altering degron motif	0.6471
p.V511M	TCGA-EE-A2GT	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.3056
p.P458S	TCGA-EE-A2MR	SKCM	TCGA	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.5641
p.P760S	TCGA-FR-A3YN	SKCM	TCGA	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1944
p.S460F	TCGA-FW-A3R5	SKCM	TCGA	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.7982
p.P458T	TCGA-G2-A2EO	BLCA	TCGA	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.5919
p.P286S	TCGA-GN-A267	SKCM	TCGA	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2222
p.L499P	TCGA-HU-A4G8	STAD	TCGA	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1389
p.T394S	TCGA-NC-A5HP	LUSC	TCGA	APTST	DEG_SPOP_SBC_1	403:407	Mutation rewiring degron network	0.0833
p.P757L	TCGA-RD-A7C1	STAD	TCGA	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.2778
p.A470T	TCGA-XC-AA0X	LUSC	TCGA	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.0556
p.A470T	SIDM00217	Colorectal Carcinoma	GDSC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.0556
p.A470T	SNU-1040	large intestine	COSMIC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.0556
p.R418W	DO48444	BLCA	ICGC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation rewiring degron network	0.0556
p.R418W	DO48444	BLCA	ICGC	AVTTS	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2222
p.R418W	ACH-000432	Leukemia	CCLE	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation rewiring degron network	0.0556
p.R418W	ACH-000432	Leukemia	CCLE	AVTTS	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2222
p.R418W	BV-173	haematopoietic and lymphoid tissue	COSMIC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation rewiring degron network	0.0556
p.R418W	BV-173	haematopoietic and lymphoid tissue	COSMIC	AVTTS	DEG_SPOP_SBC_1	422:426	Mutation rewiring degron network	0.2222
p.I502M	DO474	BLCA	ICGC	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.2222
p.P432T	DO456	BLCA	ICGC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation altering degron motif	0.7031
p.F459L	DO1158	BRCA	ICGC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.6981
p.F459L	DO228974	LICA	ICGC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.6981
p.V514I	DO44392	CESC	ICGC	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.2222
p.S750P	DO223477	CLLE	ICGC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.6752
p.E426K	DO10475	COAD	ICGC	AVTTS	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.7022
p.R308C	DO10132	COAD	ICGC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.2778
p.P742L	DO8834	COAD	ICGC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1667
p.R313Q	DO227996	COCA	ICGC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1389
p.R308H	DO222765	COCA	ICGC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.2778
p.R291K	DO222305	DLBC	ICGC	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0833
p.I433N	DO222616	ESCA	ICGC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation altering degron motif	0.728
p.P518S	DO11854	GBM	ICGC	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1111
p.S500C	DO14414	HNSC	ICGC	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1667
p.A281V	DO22237	LGG	ICGC	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.6936
p.A281V	ACH-000973	Bladder Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.6936
p.A281V	639-V	urinary tract	COSMIC	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation altering degron motif	0.6936
p.A425D	DO228948	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.7793
p.A425D	DO228971	LICA	ICGC	AVTTS	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.7793
p.P292T	DO228971	LICA	ICGC	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.0556
p.P292T	DO228971	LICA	ICGC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.0556
p.A511E	DO229019	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.3056
p.H436N	DO229026	LICA	ICGC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation altering degron motif	0.7423
p.T506N	DO229032	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	506:510	Mutation altering degron motif	0.7055
p.Q744K	DO229041	LICA	ICGC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.2222
p.I304V	DO50846	LICA	ICGC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7076
p.I304V	DO23248	LINC	ICGC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation altering degron motif	0.7076
p.P742S	DO26842	LUSC	ICGC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1667
p.A444T	DO52026	LUSC	ICGC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.1111
p.A444T	DO52026	LUSC	ICGC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation rewiring degron network	0.1111
p.A444T	ACH-000999	Colon/Colorectal Cancer	CCLE	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.1111
p.A444T	ACH-000999	Colon/Colorectal Cancer	CCLE	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation rewiring degron network	0.1111
p.A444T	SNU-1040	large intestine	COSMIC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.1111
p.A444T	SNU-1040	large intestine	COSMIC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation rewiring degron network	0.1111
p.A425V	DO222494	MELA	ICGC	AVTTS	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.6936
p.P440L	DO222702	MELA	ICGC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation rewiring degron network	0.2222
p.P518L	DO222837	MELA	ICGC	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1111
p.A755V	DO232761	PBCA	ICGC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.6936
p.A755V	DO222342	STAD	ICGC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.6936
p.P432S	DO37819	SKCM	ICGC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation altering degron motif	0.6752
p.S434F	DO37406	SKCM	ICGC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation altering degron motif	0.7982
p.P741L	DO50284	SKCM	ICGC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1389
p.P741S	DO47331	SKCM	ICGC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.1389
p.Q460H	DO51766	STAD	ICGC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation altering degron motif	0.7582
p.I758V	DO42568	UCEC	ICGC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.25
p.F462L	DO42793	UCEC	ICGC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.2778
p.A501V	DO41361	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	506:510	Mutation rewiring degron network	0.1944
p.D314H	DO41349	UCEC	ICGC	VITTT	DEG_SPOP_SBC_1	302:306	Mutation rewiring degron network	0.1111
p.H229Y	SIDM00216	Colorectal Carcinoma	GDSC	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.0556
p.R444W	SIDM00962	Chronic Myelogenous Leukemia	GDSC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.1111
p.R444W	SIDM00962	Chronic Myelogenous Leukemia	GDSC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation rewiring degron network	0.1111
p.R444W	BV-173	haematopoietic and lymphoid tissue	COSMIC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.1111
p.R444W	BV-173	haematopoietic and lymphoid tissue	COSMIC	IPVAKVVPQ	DEG_SIAH_1	428:436	Mutation rewiring degron network	0.1111
p.D448N	SIDM00660	Colorectal Carcinoma	GDSC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.2222
p.D448N	LS-411N	large intestine	COSMIC	ERSSLIPIS	DEG_APCC_DBOX_1	452:460	Mutation rewiring degron network	0.2222
p.R276W	SIDM00190	Melanoma	GDSC	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2778
p.R276W	CP66-MEL	skin	COSMIC	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.2778
p.T407A	SIDM01045	Endometrial Carcinoma	GDSC	APTST	DEG_SPOP_SBC_1	403:407	Mutation altering degron motif	0.7139
p.T407A	EN	endometrium	COSMIC	APTST	DEG_SPOP_SBC_1	403:407	Mutation altering degron motif	0.7139
p.N283I	SIDM00871	Non-Cancerous	GDSC	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.3056
p.N283I	SIDM00872	Breast Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.3056
p.N283I	ACH-000859	Breast Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	278:282	Mutation rewiring degron network	0.3056
p.V748F	SIDM01682	Gastric Carcinoma	GDSC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.7068
p.A755T	ACH-000450	Skin Cancer	CCLE	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.7139
p.A755T	MEL-HO	skin	COSMIC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation altering degron motif	0.7139
p.P745Q	ACH-000792	Kidney Cancer	CCLE	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.25
p.P745Q	BFTC-909	kidney	COSMIC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.25
p.D422N	ACH-000985	Colon/Colorectal Cancer	CCLE	AVTTS	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.6932
p.D422N	LS-411N	large intestine	COSMIC	AVTTS	DEG_SPOP_SBC_1	422:426	Mutation altering degron motif	0.6932
p.A235V	ACH-000989	Colon/Colorectal Cancer	CCLE	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2222
p.A235V	SNU-175	large intestine	COSMIC	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.2222
p.I243L	ACH-001560	Lung Cancer	CCLE	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation altering degron motif	0.7174
p.R250W	ACH-002097	Skin Cancer	CCLE	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.R250W	CP66-MEL	skin	COSMIC	VMSSS	DEG_SPOP_SBC_1	239:243	Mutation rewiring degron network	0.1389
p.A756T	MEL-HO	skin	COSMIC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.3056
p.P746Q	BFTC-909	kidney	COSMIC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.2778
p.A747T	MEL-HO	skin	COSMIC	VPITPPIT	DEG_SCF_FBW7_1	748:755	Mutation rewiring degron network	0.3056

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SAP130

UniProt ID: Q9H0E3

Entrez ID: 79595

Protein name: Histone deacetylase complex subunit SAP130 (130 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p130)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SAP130 in