DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
PITSS
Uniprot ID:
Q9H0E3
Source protein:
Histone deacetylase complex subunit SAP130
Source gene:
SAP130
Class:
DEG_SPOP_SBC_1
Location:
506:510
E3 ligase:
SPOP
DEGRON score:
0.6301
ASA_SCORE:
85.9
COIL:
0.9328
CONS_SCORE:
0.5162
DSS_SCORE:
0.2475
HELIX:
0.015
FCONS_SCORE:
1.0137
RIG_SCORE:
0.7735
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P506L
TCGA-3L-AA1B
COAD
TCGA
PITSS
DEG_SPOP_SBC_1
0.7582
p.H502Y
TCGA-94-8491
LUSC
TCGA
PITSS
DEG_SPOP_SBC_1
0.2222
p.Y497C
TCGA-BR-4361
STAD
TCGA
PITSS
DEG_SPOP_SBC_1
0.0833
p.I507M
TCGA-DK-A1A3
BLCA
TCGA
PITSS
DEG_SPOP_SBC_1
0.6507
p.V511M
TCGA-EE-A2GT
SKCM
TCGA
PITSS
DEG_SPOP_SBC_1
0.3056
p.L499P
TCGA-HU-A4G8
STAD
TCGA
PITSS
DEG_SPOP_SBC_1
0.1389
p.I502M
DO474
BLCA
ICGC
PITSS
DEG_SPOP_SBC_1
0.2222
p.V514I
DO44392
CESC
ICGC
PITSS
DEG_SPOP_SBC_1
0.2222
p.P518S
DO11854
GBM
ICGC
PITSS
DEG_SPOP_SBC_1
0.1111
p.S500C
DO14414
HNSC
ICGC
PITSS
DEG_SPOP_SBC_1
0.1667
p.A511E
DO229019
LICA
ICGC
PITSS
DEG_SPOP_SBC_1
0.3056
p.T506N
DO229032
LICA
ICGC
PITSS
DEG_SPOP_SBC_1
0.7055
p.P518L
DO222837
MELA
ICGC
PITSS
DEG_SPOP_SBC_1
0.1111
p.A501V
DO41361
UCEC
ICGC
PITSS
DEG_SPOP_SBC_1
0.1944
Drug responses associated with SAP130 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PITSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P0C7T5
Ataxin-1-like
DEG_SPOP_SBC_1
459:463
PITSS
SPOP
0.9666
More...
P49790
Nuclear pore complex protein Nup153
DEG_SPOP_SBC_1
478:482
PITSS
SPOP
0.9764
More...
P58397
A disintegrin and metalloproteinase with thrombospondin motifs 12
DEG_SPOP_SBC_1
74:78
PITSS
SPOP
0.5535
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
258:262
PITSS
SPOP
0.9141
More...
Q02505
Mucin-3A
DEG_SPOP_SBC_1
1386:1390
PITSS
SPOP
0.7751
More...
Q6EMB2
Tubulin polyglutamylase TTLL5
DEG_SPOP_SBC_1
1269:1273
PITSS
SPOP
0.9014
More...
Q8IXJ9
Polycomb group protein ASXL1
DEG_SPOP_SBC_1
1219:1223
PITSS
SPOP
0.9345
More...
Q8TAM2
Tetratricopeptide repeat protein 8
DEG_SPOP_SBC_1
150:154
PITSS
SPOP
0.9945
More...
Q9H0E3
Histone deacetylase complex subunit SAP130
DEG_SPOP_SBC_1
506:510
PITSS
SPOP
0.6301
More...
Q52LA3
Protein lin-52 homolog
DEG_SPOP_SBC_1
49:53
PITSS
SPOP
0.9964
More...