DegronMD - Q52LA3(LIN52)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R63C	TCGA-A5-A0G9	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0556
p.R63C	DO42304	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0556
p.V39A	TCGA-AM-5821	COAD	TCGA	PITSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0556
p.V39A	DO8240	COAD	ICGC	PITSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0556
p.S48N	TCGA-DU-6407	LGG	TCGA	PITSS	DEG_SPOP_SBC_1	49:53	Mutation blocking phosphorylation signal	0.75
p.S48N	DO22295	LGG	ICGC	PITSS	DEG_SPOP_SBC_1	49:53	Mutation blocking phosphorylation signal	0.75
p.R63L	DO228971	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0556
p.V39F	DO229019	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.0556
p.A59T	SIDM00150	Colorectal Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1667
p.A59T	ACH-000969	Colon/Colorectal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1667
p.A59T	KM12	large intestine	COSMIC	PITSS	DEG_SPOP_SBC_1	49:53	Mutation rewiring degron network	0.1667
p.S48R	ACH-000725	Breast Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	49:53	Mutation blocking phosphorylation signal	0.75

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons