DegronMD

Uniprot ID: Q52LA3

Source protein: Protein lin-52 homolog

Source gene: LIN52

Class: DEG_SPOP_SBC_1

Location: 49:53

E3 ligase: SPOP

DEGRON score: 0.9964

ASA_SCORE: 81.92

COIL: 0.9358

CONS_SCORE: 0.3825

DSS_SCORE: 0.3853

HELIX: 0.0408

FCONS_SCORE: 0.7614

RIG_SCORE: 0.6634

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R63C	TCGA-A5-A0G9	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	0.0556
p.R63C	DO42304	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	0.0556
p.V39A	TCGA-AM-5821	COAD	TCGA	PITSS	DEG_SPOP_SBC_1	0.0556
p.V39A	DO8240	COAD	ICGC	PITSS	DEG_SPOP_SBC_1	0.0556
p.S48N	TCGA-DU-6407	LGG	TCGA	PITSS	DEG_SPOP_SBC_1	0.75
p.S48N	DO22295	LGG	ICGC	PITSS	DEG_SPOP_SBC_1	0.75
p.R63L	DO228971	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	0.0556
p.V39F	DO229019	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	0.0556
p.A59T	SIDM00150	Colorectal Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	0.1667
p.A59T	ACH-000969	Colon/Colorectal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.1667
p.A59T	KM12	large_intestine	COSMIC	PITSS	DEG_SPOP_SBC_1	0.1667
p.S48R	ACH-000725	Breast Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.75

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C7T5	Ataxin-1-like	DEG_SPOP_SBC_1	459:463	PITSS	SPOP	0.9666	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	478:482	PITSS	SPOP	0.9764	More...
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	74:78	PITSS	SPOP	0.5535	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	258:262	PITSS	SPOP	0.9141	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1386:1390	PITSS	SPOP	0.7751	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_SPOP_SBC_1	1269:1273	PITSS	SPOP	0.9014	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	1219:1223	PITSS	SPOP	0.9345	More...
Q8TAM2	Tetratricopeptide repeat protein 8	DEG_SPOP_SBC_1	150:154	PITSS	SPOP	0.9945	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	506:510	PITSS	SPOP	0.6301	More...
Q52LA3	Protein lin-52 homolog	DEG_SPOP_SBC_1	49:53	PITSS	SPOP	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons