DegronMD - Q6EMB2(TTLL5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A624S	TCGA-A5-A0G2	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.1667
p.A1277T	TCGA-AX-A05S	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.2222
p.A1277T	DO43218	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.2222
p.T623S	TCGA-AX-A2H5	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.1389
p.S1273C	TCGA-CD-8525	STAD	TCGA	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7541
p.S1273C	DO47763	STAD	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.7541
p.P1264T	TCGA-D3-A2J6	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1944
p.P1264T	DO37901	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1944
p.L625F	TCGA-EE-A2MM	SKCM	TCGA	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.1944
p.S634P	TCGA-FI-A2D5	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation altering degron motif	0.5641
p.P1264S	DO223587	CLLE	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1944
p.F1267S	DO229010	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.2778
p.F1267S	DO229016	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.2778
p.F1267S	DO229346	LAML	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.2778
p.F1267S	DO228941	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.2778
p.F1267S	DO231207	LUSC	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.2778
p.R1264H	DO228123	EOPC	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1944
p.N628S	DO233880	GACA	ICGC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2778
p.N642H	DO233918	GACA	ICGC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.1111
p.A1265S	DO229035	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.2222
p.T1263N	DO23158	LINC	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1667
p.A1266V	DO220885	MELA	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.25
p.V1268M	DO233295	NACA	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.3056
p.S1261I	DO233296	NACA	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1111
p.S1268C	DO46611	OV	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.3056
p.R1264S	DO37523	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1944
p.L639F	DO37770	SKCM	ICGC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.1944
p.E620K	DO37499	SKCM	ICGC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.0556
p.A638S	DO41235	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2222
p.T637S	DO41157	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.25
p.K636E	SIDM00371	Pancreatic Carcinoma	GDSC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2778
p.K636E	SIDM00370	T-Lymphoblastic Leukemia	GDSC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2778
p.K636E	TALL-1	haematopoietic and lymphoid tissue	COSMIC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2778
p.K636E	SUIT-2	pancreas	COSMIC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2778
p.R638H	SIDM00781	Colorectal Carcinoma	GDSC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2222
p.R638H	SNU-C2B	large intestine	COSMIC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.2222
p.T1271S	SIDM01118	Small Cell Lung Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.6005
p.T1271S	ACH-002175	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.6005
p.T1271S	NCI-H740	lung	COSMIC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation altering degron motif	0.6005
p.V1268A	SIDM00863	Burkitt's Lymphoma	GDSC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.3056
p.E620D	ACH-000360	Colon/Colorectal Cancer	CCLE	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.0556
p.E620D	NCI-H508	large intestine	COSMIC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.0556
p.F1277S	ACH-000670	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.2222
p.F1277S	SBC-5	lung	COSMIC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.2222
p.Y632H	ACH-000767	Lung Cancer	CCLE	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation altering degron motif	0.7229
p.R1264C	ACH-000950	Colon/Colorectal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1944
p.R1264C	LoVo	large intestine	COSMIC	PITSS	DEG_SPOP_SBC_1	1269:1273	Mutation rewiring degron network	0.1944
p.V635A	IM-95	stomach	COSMIC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.3056
p.G623R	CW-2	large intestine	COSMIC	PKENS	DEG_APCC_KENBOX_2	630:634	Mutation rewiring degron network	0.1389

Kaplan plot for TTLL5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTLL5

UniProt ID: Q6EMB2

Entrez ID: 23093

Protein name: Tubulin polyglutamylase TTLL5 (EC 6.3.2.-) (SRC1 and TIF2-associated modulatory protein) (STAMP protein) (Tubulin--tyrosine ligase-like protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTLL5 in