DegronMD

Uniprot ID: Q6EMB2

Source protein: Tubulin polyglutamylase TTLL5

Source gene: TTLL5

Class: DEG_APCC_KENBOX_2

Location: 630:634

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.983

ASA_SCORE: 98.1

COIL: 0.7642

CONS_SCORE: 0.2566

DSS_SCORE: 0.4963

HELIX: 0.1454

FCONS_SCORE: 1.0728

RIG_SCORE: 0.7049

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A624S	TCGA-A5-A0G2	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	0.1667
p.T623S	TCGA-AX-A2H5	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	0.1389
p.L625F	TCGA-EE-A2MM	SKCM	TCGA	PKENS	DEG_APCC_KENBOX_2	0.1944
p.S634P	TCGA-FI-A2D5	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	0.5641
p.N628S	DO233880	GACA	ICGC	PKENS	DEG_APCC_KENBOX_2	0.2778
p.N642H	DO233918	GACA	ICGC	PKENS	DEG_APCC_KENBOX_2	0.1111
p.L639F	DO37770	SKCM	ICGC	PKENS	DEG_APCC_KENBOX_2	0.1944
p.E620K	DO37499	SKCM	ICGC	PKENS	DEG_APCC_KENBOX_2	0.0556
p.A638S	DO41235	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	0.2222
p.T637S	DO41157	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	0.25
p.K636E	SIDM00371	Pancreatic Carcinoma	GDSC	PKENS	DEG_APCC_KENBOX_2	0.2778
p.K636E	SIDM00370	T-Lymphoblastic Leukemia	GDSC	PKENS	DEG_APCC_KENBOX_2	0.2778
p.K636E	TALL-1	haematopoietic_and_lymphoid_tissue	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.2778
p.K636E	SUIT-2	pancreas	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.2778
p.R638H	SIDM00781	Colorectal Carcinoma	GDSC	PKENS	DEG_APCC_KENBOX_2	0.2222
p.R638H	SNU-C2B	large_intestine	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.2222
p.E620D	ACH-000360	Colon/Colorectal Cancer	CCLE	PKENS	DEG_APCC_KENBOX_2	0.0556
p.E620D	NCI-H508	large_intestine	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.0556
p.Y632H	ACH-000767	Lung Cancer	CCLE	PKENS	DEG_APCC_KENBOX_2	0.7229
p.V635A	IM-95	stomach	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.3056
p.G623R	CW-2	large_intestine	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43164	E3 ubiquitin-protein ligase Praja-2	DEG_APCC_KENBOX_2	72:76	PKENS	APC,CDC20,FZR1	0.9147	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_APCC_KENBOX_2	630:634	PKENS	APC,CDC20,FZR1	0.983	More...
Q86W42	THO complex subunit 6 homolog	DEG_APCC_KENBOX_2	136:140	PKENS	APC,CDC20,FZR1	0.6367	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_APCC_KENBOX_2	186:190	PKENS	APC,CDC20,FZR1	0.9681	More...
Q9P260	RAB11-binding protein RELCH	DEG_APCC_KENBOX_2	449:453	PKENS	APC,CDC20,FZR1	0.7041	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons