DegronMD - O43164(PJA2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L66F	TCGA-05-4396	LUAD	TCGA	PKENS	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1667
p.L66F	DO23838	LUAD	ICGC	PKENS	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1667
p.R227K	TCGA-AC-A2B8	BRCA	TCGA	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1944
p.R227K	DO5884	BRCA	ICGC	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1944
p.D228N	TCGA-BH-A0HA	BRCA	TCGA	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1667
p.D228N	DO1658	BRCA	ICGC	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation rewiring degron network	0.1667
p.V71G	TCGA-EO-A22R	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.3056
p.V71G	DO42713	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.3056
p.D83N	TCGA-IG-A5B8	ESCA	TCGA	PKENS	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1389
p.P81R	TCGA-LN-A5U7	ESCA	TCGA	PKENS	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1944
p.A211V	DO234286	ESAD	ICGC	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation rewiring degron network	0.2778
p.P81L	DO228761	GACA	ICGC	PKENS	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1944
p.P220L	DO228947	LICA	ICGC	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation altering degron motif	0.7582
p.P220L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation altering degron motif	0.7582
p.P220L	SIDM00324	Neuroblastoma	GDSC	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation altering degron motif	0.7582
p.P218Q	DO229015	LICA	ICGC	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation altering degron motif	0.5924
p.P218A	SIDM00690	Head and Neck Carcinoma	GDSC	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation altering degron motif	0.6392
p.P218A	ACH-002251	Head and Neck Cancer	CCLE	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation altering degron motif	0.6392
p.P218A	JHU-029	upper aerodigestive tract	COSMIC	TGLSPPVPSF	DEG_COP1_1	213:222	Mutation altering degron motif	0.6392
p.V65L	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PKENS	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1389
p.V65L	ACH-000916	Lung Cancer	CCLE	PKENS	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1389
p.V65L	NCI-H1573	lung	COSMIC	PKENS	DEG_APCC_KENBOX_2	72:76	Mutation rewiring degron network	0.1389

Kaplan plot for PJA2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PJA2

UniProt ID: O43164

Entrez ID: 9867

Protein name: E3 ubiquitin-protein ligase Praja-2 (Praja2) (EC 2.3.2.27) (RING finger protein 131) (RING-type E3 ubiquitin transferase Praja-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PJA2 in