DegronMD

Uniprot ID: O43164

Source protein: E3 ubiquitin-protein ligase Praja-2

Source gene: PJA2

Class: DEG_APCC_KENBOX_2

Location: 72:76

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9147

ASA_SCORE: 94.34

COIL: 0.7602

CONS_SCORE: 0.3246

DSS_SCORE: 0.6265

HELIX: 0.1456

FCONS_SCORE: 1.0218

RIG_SCORE: 0.614

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L66F	TCGA-05-4396	LUAD	TCGA	PKENS	DEG_APCC_KENBOX_2	0.1667
p.L66F	DO23838	LUAD	ICGC	PKENS	DEG_APCC_KENBOX_2	0.1667
p.V71G	TCGA-EO-A22R	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	0.3056
p.V71G	DO42713	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	0.3056
p.D83N	TCGA-IG-A5B8	ESCA	TCGA	PKENS	DEG_APCC_KENBOX_2	0.1389
p.P81R	TCGA-LN-A5U7	ESCA	TCGA	PKENS	DEG_APCC_KENBOX_2	0.1944
p.P81L	DO228761	GACA	ICGC	PKENS	DEG_APCC_KENBOX_2	0.1944
p.V65L	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	PKENS	DEG_APCC_KENBOX_2	0.1389
p.V65L	ACH-000916	Lung Cancer	CCLE	PKENS	DEG_APCC_KENBOX_2	0.1389
p.V65L	NCI-H1573	lung	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43164	E3 ubiquitin-protein ligase Praja-2	DEG_APCC_KENBOX_2	72:76	PKENS	APC,CDC20,FZR1	0.9147	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_APCC_KENBOX_2	630:634	PKENS	APC,CDC20,FZR1	0.983	More...
Q86W42	THO complex subunit 6 homolog	DEG_APCC_KENBOX_2	136:140	PKENS	APC,CDC20,FZR1	0.6367	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_APCC_KENBOX_2	186:190	PKENS	APC,CDC20,FZR1	0.9681	More...
Q9P260	RAB11-binding protein RELCH	DEG_APCC_KENBOX_2	449:453	PKENS	APC,CDC20,FZR1	0.7041	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons