DegronMD

Uniprot ID: Q9P260

Source protein: RAB11-binding protein RELCH

Source gene: RELCH

Class: DEG_APCC_KENBOX_2

Location: 449:453

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7041

ASA_SCORE: 92.76

COIL: 0.8718

CONS_SCORE: 0.3131

DSS_SCORE: 0.7392

HELIX: 0.083

FCONS_SCORE: 0.9801

RIG_SCORE: 0.597

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P449L	SIDM01025	Esophageal Squamous Cell Carcinoma	GDSC	PKENS	DEG_APCC_KENBOX_2	0.6471
p.P449L	KYSE-520	oesophagus	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.6471

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43164	E3 ubiquitin-protein ligase Praja-2	DEG_APCC_KENBOX_2	72:76	PKENS	APC,CDC20,FZR1	0.9147	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_APCC_KENBOX_2	630:634	PKENS	APC,CDC20,FZR1	0.983	More...
Q86W42	THO complex subunit 6 homolog	DEG_APCC_KENBOX_2	136:140	PKENS	APC,CDC20,FZR1	0.6367	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_APCC_KENBOX_2	186:190	PKENS	APC,CDC20,FZR1	0.9681	More...
Q9P260	RAB11-binding protein RELCH	DEG_APCC_KENBOX_2	449:453	PKENS	APC,CDC20,FZR1	0.7041	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons