MARCHF7
UniProt ID: Q9H992
Entrez ID: 64844
Protein name: E3 ubiquitin-protein ligase MARCHF7 (EC 2.3.2.27) (Axotrophin) (Membrane-associated RING finger protein 7) (Membrane-associated RING-CH protein VII) (MARCH-VII) (RING finger protein 177) (RING-type E3 ubiquitin transferase MARCHF7)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in...
FUNCTION: E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). {ECO:0000250|UniProtKB:Q9WV66, ECO:0000269|PubMed:16868077, ECO:0000269|PubMed:31270356}.
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GO - Biological processes (BP):
negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal protein catabolic process [GO:1901799]; ne...
negative regulation of DNA damage response, signal transduction by p53 class mediator [GO:0043518]; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [GO:1902166]; negative regulation of proteasomal protein catabolic process [GO:1901799]; negative regulation of protein autoubiquitination [GO:1905524]; negative regulation of T cell proliferation [GO:0042130]; positive regulation of cell population proliferation [GO:0008284]; positive regulation of protein polyubiquitination [GO:1902916]; protein autoubiquitination [GO:0051865]; protein monoubiquitination [GO:0006513]; protein stabilization [GO:0050821]; regulation of tolerance induction [GO:0002643]
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GO - Molecular function (MF):
MDM2/MDM4 family protein binding [GO:0097371]; transferase activity [GO:0016740]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; zinc ion binding [GO:0008270]...
MDM2/MDM4 family protein binding [GO:0097371]; transferase activity [GO:0016740]; ubiquitin binding [GO:0043130]; ubiquitin conjugating enzyme binding [GO:0031624]; zinc ion binding [GO:0008270]
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GO - Cellular component (CC):
cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]...
cytosol [GO:0005829]; nucleus [GO:0005634]; plasma membrane [GO:0005886]
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MARCHF7
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Kaplan plot for MARCHF7 in
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*NOTE: the Kaplan plots were collected from OncoLnc