DegronMD

Uniprot ID: Q9H992

Source protein: E3 ubiquitin-protein ligase MARCHF7

Source gene: MARCHF7

Class: DEG_APCC_DBOX_1

Location: 279:287

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9972

ASA_SCORE: 80.0889

COIL: 0.2712

CONS_SCORE: 0.8251

DSS_SCORE: 0.5212

HELIX: 0.7136

FCONS_SCORE: 1.2971

RIG_SCORE: 0.7626

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R285C	SIDM00945	Colorectal Carcinoma	GDSC	TRRLLSRIA	DEG_APCC_DBOX_1	0.719
p.E274G	SIDM00457	Plasma Cell Myeloma	GDSC	TRRLLSRIA	DEG_APCC_DBOX_1	0.1944
p.T279A	SIDM00199	Chondrosarcoma	GDSC	TRRLLSRIA	DEG_APCC_DBOX_1	0.6028
p.S289I	SIDM00658	Non-Small Cell Lung Carcinoma	GDSC	TRRLLSRIA	DEG_APCC_DBOX_1	0.2778
p.R280S	SIDM00859	B-Cell Non-Hodgkin's Lymphoma	GDSC	TRRLLSRIA	DEG_APCC_DBOX_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_APCC_DBOX_1	279:287	TRRLLSRIA	APC,CDC20,FZR1	0.9972	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons