DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
RRWGLSSLS
Uniprot ID:
Q9H992
Source protein:
E3 ubiquitin-protein ligase MARCHF7
Source gene:
MARCHF7
Class:
DEG_APCC_DBOX_1
Location:
353:361
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.9703
ASA_SCORE:
87.8556
COIL:
0.7233
CONS_SCORE:
0.6551
DSS_SCORE:
0.3776
HELIX:
0.1811
FCONS_SCORE:
1.1622
RIG_SCORE:
0.6565
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A344D
SIDM00789
Colorectal Carcinoma
GDSC
RRWGLSSLS
DEG_APCC_DBOX_1
0.0833
p.L351F
SIDM00284
Melanoma
GDSC
RRWGLSSLS
DEG_APCC_DBOX_1
0.2778
Drug responses associated with MARCHF7 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of RRWGLSSLS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9H992
E3 ubiquitin-protein ligase MARCHF7
DEG_APCC_DBOX_1
353:361
RRWGLSSLS
APC,CDC20,FZR1
0.9703
More...