DegronMD

Uniprot ID: Q86W42

Source protein: THO complex subunit 6 homolog

Source gene: THOC6

Class: DEG_APCC_KENBOX_2

Location: 136:140

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6367

ASA_SCORE: 68.44

COIL: 0.7858

CONS_SCORE: 0.4694

DSS_SCORE: 0.1245

HELIX: 0.0104

FCONS_SCORE: 0.8861

RIG_SCORE: 0.8315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.N130H	TCGA-12-0829	GBM	TCGA	PKENS	DEG_APCC_KENBOX_2	0.1667
p.N130H	DO11166	GBM	ICGC	PKENS	DEG_APCC_KENBOX_2	0.1667
p.P127A	TCGA-25-1326	OV	TCGA	PKENS	DEG_APCC_KENBOX_2	0.0833
p.P127A	DO28154	OV	ICGC	PKENS	DEG_APCC_KENBOX_2	0.0833
p.E138D	TCGA-A5-A1OF	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	0.6758
p.E138D	TCGA-A5-A2K5	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	0.6758
p.E138D	TCGA-BS-A0UV	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	0.6758
p.E138D	TCGA-D1-A103	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	0.6758
p.E138D	DO42312	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	0.6758
p.E138D	DO42568	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	0.6758
p.E138D	DO42793	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	0.6758
p.E138D	DO41379	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	0.6758
p.S140F	TCGA-AA-A010	COAD	TCGA	PKENS	DEG_APCC_KENBOX_2	0.6871
p.S140F	DO220886	MELA	ICGC	PKENS	DEG_APCC_KENBOX_2	0.6871
p.S140F	DO222644	MELA	ICGC	PKENS	DEG_APCC_KENBOX_2	0.6871
p.L141I	TCGA-B0-5098	KIRC	TCGA	PKENS	DEG_APCC_KENBOX_2	0.3056
p.L141I	DO18938	KIRC	ICGC	PKENS	DEG_APCC_KENBOX_2	0.3056
p.L143M	TCGA-EE-A2MG	SKCM	TCGA	PKENS	DEG_APCC_KENBOX_2	0.25
p.L143M	DO37421	SKCM	ICGC	PKENS	DEG_APCC_KENBOX_2	0.25
p.A131D	TCGA-EJ-7782	PRAD	TCGA	PKENS	DEG_APCC_KENBOX_2	0.1944
p.A131D	DO36256	PRAD	ICGC	PKENS	DEG_APCC_KENBOX_2	0.1944
p.Q149E	DO233189	GACA	ICGC	PKENS	DEG_APCC_KENBOX_2	0.0833
p.Q149H	SIDM01040	Ovarian Carcinoma	GDSC	PKENS	DEG_APCC_KENBOX_2	0.0833
p.Q149H	ACH-000574	Ovarian Cancer	CCLE	PKENS	DEG_APCC_KENBOX_2	0.0833
p.Q149H	FU-OV-1	ovary	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.0833
p.G134W	KE-37	haematopoietic_and_lymphoid_tissue	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.2778
p.Y146C	NTERA-2_cl_D1	testis	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.1667
p.Y146C	COLO-668	lung	COSMIC	PKENS	DEG_APCC_KENBOX_2	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43164	E3 ubiquitin-protein ligase Praja-2	DEG_APCC_KENBOX_2	72:76	PKENS	APC,CDC20,FZR1	0.9147	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_APCC_KENBOX_2	630:634	PKENS	APC,CDC20,FZR1	0.983	More...
Q86W42	THO complex subunit 6 homolog	DEG_APCC_KENBOX_2	136:140	PKENS	APC,CDC20,FZR1	0.6367	More...
Q9H992	E3 ubiquitin-protein ligase MARCHF7	DEG_APCC_KENBOX_2	186:190	PKENS	APC,CDC20,FZR1	0.9681	More...
Q9P260	RAB11-binding protein RELCH	DEG_APCC_KENBOX_2	449:453	PKENS	APC,CDC20,FZR1	0.7041	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PKENS

Degron related mutations and impact score

Drug responses associated with THOC6 mutations

All proteins holding degron of PKENS