DegronMD - Q86W42(THOC6)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N130H	TCGA-12-0829	GBM	TCGA	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1667
p.N130H	DO11166	GBM	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1667
p.P127A	TCGA-25-1326	OV	TCGA	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0833
p.P127A	DO28154	OV	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0833
p.E138D	TCGA-A5-A1OF	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6758
p.E138D	TCGA-A5-A2K5	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6758
p.E138D	TCGA-BS-A0UV	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6758
p.E138D	TCGA-D1-A103	UCEC	TCGA	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6758
p.E138D	DO42312	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6758
p.E138D	DO42568	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6758
p.E138D	DO42793	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6758
p.E138D	DO41379	UCEC	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6758
p.S140F	TCGA-AA-A010	COAD	TCGA	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6871
p.S140F	DO220886	MELA	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6871
p.S140F	DO222644	MELA	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation altering degron motif	0.6871
p.L141I	TCGA-B0-5098	KIRC	TCGA	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.3056
p.L141I	DO18938	KIRC	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.3056
p.L143M	TCGA-EE-A2MG	SKCM	TCGA	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.25
p.L143M	DO37421	SKCM	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.25
p.A131D	TCGA-EJ-7782	PRAD	TCGA	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1944
p.A131D	DO36256	PRAD	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1944
p.Q149E	DO233189	GACA	ICGC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0833
p.Q149H	SIDM01040	Ovarian Carcinoma	GDSC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0833
p.Q149H	ACH-000574	Ovarian Cancer	CCLE	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0833
p.Q149H	FU-OV-1	ovary	COSMIC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.0833
p.G134W	KE-37	haematopoietic and lymphoid tissue	COSMIC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.2778
p.Y146C	NTERA-2_cl_D1	testis	COSMIC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1667
p.Y146C	COLO-668	lung	COSMIC	PKENS	DEG_APCC_KENBOX_2	136:140	Mutation rewiring degron network	0.1667

Kaplan plot for THOC6 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THOC6

UniProt ID: Q86W42

Entrez ID: 79228

Protein name: THO complex subunit 6 homolog (Functional spliceosome-associated protein 35) (fSAP35) (WD repeat-containing protein 58)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THOC6 in