DegronMD

Uniprot ID: O43164

Source protein: E3 ubiquitin-protein ligase Praja-2

Source gene: PJA2

Class: DEG_COP1_1

Location: 213:222

E3 ligase: COP1

DEGRON score: 0.9975

ASA_SCORE: 67.42

COIL: 0.8984

CONS_SCORE: 0.3027

DSS_SCORE: 0.442

HELIX: 0.0511

FCONS_SCORE: 0.8718

RIG_SCORE: 0.7055

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R227K	TCGA-AC-A2B8	BRCA	TCGA	TGLSPPVPSF	DEG_COP1_1	0.1944
p.R227K	DO5884	BRCA	ICGC	TGLSPPVPSF	DEG_COP1_1	0.1944
p.D228N	TCGA-BH-A0HA	BRCA	TCGA	TGLSPPVPSF	DEG_COP1_1	0.1667
p.D228N	DO1658	BRCA	ICGC	TGLSPPVPSF	DEG_COP1_1	0.1667
p.A211V	DO234286	ESAD	ICGC	TGLSPPVPSF	DEG_COP1_1	0.2778
p.P220L	DO228947	LICA	ICGC	TGLSPPVPSF	DEG_COP1_1	0.7582
p.P220L	SIDM01259	B-Lymphoblastic Leukemia	GDSC	TGLSPPVPSF	DEG_COP1_1	0.7582
p.P220L	SIDM00324	Neuroblastoma	GDSC	TGLSPPVPSF	DEG_COP1_1	0.7582
p.P218Q	DO229015	LICA	ICGC	TGLSPPVPSF	DEG_COP1_1	0.5924
p.P218A	SIDM00690	Head and Neck Carcinoma	GDSC	TGLSPPVPSF	DEG_COP1_1	0.6392
p.P218A	ACH-002251	Head and Neck Cancer	CCLE	TGLSPPVPSF	DEG_COP1_1	0.6392
p.P218A	JHU-029	upper_aerodigestive_tract	COSMIC	TGLSPPVPSF	DEG_COP1_1	0.6392

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O43164	E3 ubiquitin-protein ligase Praja-2	DEG_COP1_1	213:222	TGLSPPVPSF	COP1	0.9975	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons