DegronMD

Uniprot ID: Q6EMB2

Source protein: Tubulin polyglutamylase TTLL5

Source gene: TTLL5

Class: DEG_SPOP_SBC_1

Location: 1269:1273

E3 ligase: SPOP

DEGRON score: 0.9014

ASA_SCORE: 72.44

COIL: 0.8244

CONS_SCORE: 0.2028

DSS_SCORE: 0.5396

HELIX: 0.0274

FCONS_SCORE: 0.9973

RIG_SCORE: 0.69

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A1277T	TCGA-AX-A05S	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	0.2222
p.A1277T	DO43218	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	0.2222
p.S1273C	TCGA-CD-8525	STAD	TCGA	PITSS	DEG_SPOP_SBC_1	0.7541
p.S1273C	DO47763	STAD	ICGC	PITSS	DEG_SPOP_SBC_1	0.7541
p.P1264T	TCGA-D3-A2J6	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	0.1944
p.P1264T	DO37901	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	0.1944
p.P1264S	DO223587	CLLE	ICGC	PITSS	DEG_SPOP_SBC_1	0.1944
p.F1267S	DO229010	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.2778
p.F1267S	DO229016	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.2778
p.F1267S	DO229346	LAML	ICGC	PITSS	DEG_SPOP_SBC_1	0.2778
p.F1267S	DO228941	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	0.2778
p.F1267S	DO231207	LUSC	ICGC	PITSS	DEG_SPOP_SBC_1	0.2778
p.R1264H	DO228123	EOPC	ICGC	PITSS	DEG_SPOP_SBC_1	0.1944
p.A1265S	DO229035	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	0.2222
p.T1263N	DO23158	LINC	ICGC	PITSS	DEG_SPOP_SBC_1	0.1667
p.A1266V	DO220885	MELA	ICGC	PITSS	DEG_SPOP_SBC_1	0.25
p.V1268M	DO233295	NACA	ICGC	PITSS	DEG_SPOP_SBC_1	0.3056
p.S1261I	DO233296	NACA	ICGC	PITSS	DEG_SPOP_SBC_1	0.1111
p.S1268C	DO46611	OV	ICGC	PITSS	DEG_SPOP_SBC_1	0.3056
p.R1264S	DO37523	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	0.1944
p.T1271S	SIDM01118	Small Cell Lung Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	0.6005
p.T1271S	ACH-002175	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.6005
p.T1271S	NCI-H740	lung	COSMIC	PITSS	DEG_SPOP_SBC_1	0.6005
p.V1268A	SIDM00863	Burkitt's Lymphoma	GDSC	PITSS	DEG_SPOP_SBC_1	0.3056
p.F1277S	ACH-000670	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.2222
p.F1277S	SBC-5	lung	COSMIC	PITSS	DEG_SPOP_SBC_1	0.2222
p.R1264C	ACH-000950	Colon/Colorectal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.1944
p.R1264C	LoVo	large_intestine	COSMIC	PITSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C7T5	Ataxin-1-like	DEG_SPOP_SBC_1	459:463	PITSS	SPOP	0.9666	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	478:482	PITSS	SPOP	0.9764	More...
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	74:78	PITSS	SPOP	0.5535	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	258:262	PITSS	SPOP	0.9141	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1386:1390	PITSS	SPOP	0.7751	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_SPOP_SBC_1	1269:1273	PITSS	SPOP	0.9014	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	1219:1223	PITSS	SPOP	0.9345	More...
Q8TAM2	Tetratricopeptide repeat protein 8	DEG_SPOP_SBC_1	150:154	PITSS	SPOP	0.9945	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	506:510	PITSS	SPOP	0.6301	More...
Q52LA3	Protein lin-52 homolog	DEG_SPOP_SBC_1	49:53	PITSS	SPOP	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PITSS

Degron related mutations and impact score

Drug responses associated with TTLL5 mutations

All proteins holding degron of PITSS