DegronMD

Uniprot ID: P58397

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 12

Source gene: ADAMTS12

Class: DEG_SPOP_SBC_1

Location: 74:78

E3 ligase: SPOP

DEGRON score: 0.5535

ASA_SCORE: 82.66

COIL: 0.9126

CONS_SCORE: 0.2735

DSS_SCORE: 0.1923

HELIX: 0.0538

FCONS_SCORE: 0.8108

RIG_SCORE: 0.7891

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H65N	TCGA-33-4566	LUSC	TCGA	PITSS	DEG_SPOP_SBC_1	0.0833
p.H65N	DO26790	LUSC	ICGC	PITSS	DEG_SPOP_SBC_1	0.0833
p.F66L	TCGA-B5-A0JY	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	0.1111
p.F66L	DO43041	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	0.1111
p.G86S	TCGA-DK-AA6U	BLCA	TCGA	PITSS	DEG_SPOP_SBC_1	0.1111
p.G86S	DO219008	BLCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.1111
p.G70S	TCGA-PK-A5HB	ACC	TCGA	PITSS	DEG_SPOP_SBC_1	0.2222
p.L84V	DO233906	GACA	ICGC	PITSS	DEG_SPOP_SBC_1	0.1667
p.P74L	DO222843	MELA	ICGC	PITSS	DEG_SPOP_SBC_1	0.7582
p.D85G	ACH-000982	Colon/Colorectal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C7T5	Ataxin-1-like	DEG_SPOP_SBC_1	459:463	PITSS	SPOP	0.9666	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	478:482	PITSS	SPOP	0.9764	More...
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	74:78	PITSS	SPOP	0.5535	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	258:262	PITSS	SPOP	0.9141	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1386:1390	PITSS	SPOP	0.7751	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_SPOP_SBC_1	1269:1273	PITSS	SPOP	0.9014	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	1219:1223	PITSS	SPOP	0.9345	More...
Q8TAM2	Tetratricopeptide repeat protein 8	DEG_SPOP_SBC_1	150:154	PITSS	SPOP	0.9945	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	506:510	PITSS	SPOP	0.6301	More...
Q52LA3	Protein lin-52 homolog	DEG_SPOP_SBC_1	49:53	PITSS	SPOP	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons