DegronMD

Uniprot ID: Q02505

Source protein: Mucin-3A

Source gene: MUC3A

Class: DEG_SPOP_SBC_1

Location: 258:262

E3 ligase: SPOP

DEGRON score: 0.9141

ASA_SCORE: 94.4

COIL: 0.939

CONS_SCORE: 0.4534

DSS_SCORE: 0.4362

HELIX: 0.0132

FCONS_SCORE: 1

RIG_SCORE: 0.7342

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S271R	TCGA-05-4427	LUAD	TCGA	PITSS	DEG_SPOP_SBC_1	0.0833
p.S271R	DO23666	LUAD	ICGC	PITSS	DEG_SPOP_SBC_1	0.0833
p.S249F	TCGA-BF-AAP0	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	0.0833
p.S249F	DO219462	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	0.0833
p.V269M	TCGA-C4-A0EZ	BLCA	TCGA	PITSS	DEG_SPOP_SBC_1	0.1389
p.V269M	DO476	BLCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.1389
p.S257F	TCGA-D3-A2JF	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	0.3056
p.S257F	DO38153	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	0.3056
p.S257F	SIDM00140	Melanoma	GDSC	PITSS	DEG_SPOP_SBC_1	0.3056
p.S257F	ACH-000968	Skin Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.3056
p.S257F	COLO-792	skin	COSMIC	PITSS	DEG_SPOP_SBC_1	0.3056
p.S265F	TCGA-EE-A2MU	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	0.25
p.S265F	DO37436	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	0.25
p.S265F	ACH-000960	Leukemia	CCLE	PITSS	DEG_SPOP_SBC_1	0.25
p.T248N	TCGA-EO-A3AY	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	0.0556
p.T248N	DO43202	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	0.0556
p.I269N	TCGA-NJ-A4YI	LUAD	TCGA	PITSS	DEG_SPOP_SBC_1	0.1389
p.I269N	DO218942	LUAD	ICGC	PITSS	DEG_SPOP_SBC_1	0.1389
p.P264S	TCGA-WE-AAA3	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	0.2778
p.P264S	DO229465	SKCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.2778
p.P264S	DO51295	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	0.2778
p.S262T	DO224639	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6005
p.S262T	DO224812	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6005
p.S262T	DO229010	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6005
p.S262T	DO229013	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6005
p.S262T	DO229016	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6005
p.S262T	DO229003	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6005
p.S262T	DO229005	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6005
p.S262T	DO229259	THCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6005
p.S262T	DO229257	THCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6005
p.S262T	DO229213	THCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6005
p.S257A	DO229010	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.3056
p.S257A	DO229013	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.3056
p.S257A	DO229016	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.3056
p.S257A	DO229003	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.3056
p.S257A	DO229005	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.3056
p.P258S	DO229010	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6752
p.P258S	DO229013	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6752
p.P258S	DO229005	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6752
p.P258S	DO230659	LAML	ICGC	PITSS	DEG_SPOP_SBC_1	0.6752
p.P258S	DO51022	LAML	ICGC	PITSS	DEG_SPOP_SBC_1	0.6752
p.P258S	DO231140	LAML	ICGC	PITSS	DEG_SPOP_SBC_1	0.6752
p.P258S	DO229047	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6752
p.S251C	DO224599	LUSC	ICGC	PITSS	DEG_SPOP_SBC_1	0.1389
p.P267T	ACH-001377	Pancreatic Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C7T5	Ataxin-1-like	DEG_SPOP_SBC_1	459:463	PITSS	SPOP	0.9666	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	478:482	PITSS	SPOP	0.9764	More...
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	74:78	PITSS	SPOP	0.5535	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	258:262	PITSS	SPOP	0.9141	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1386:1390	PITSS	SPOP	0.7751	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_SPOP_SBC_1	1269:1273	PITSS	SPOP	0.9014	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	1219:1223	PITSS	SPOP	0.9345	More...
Q8TAM2	Tetratricopeptide repeat protein 8	DEG_SPOP_SBC_1	150:154	PITSS	SPOP	0.9945	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	506:510	PITSS	SPOP	0.6301	More...
Q52LA3	Protein lin-52 homolog	DEG_SPOP_SBC_1	49:53	PITSS	SPOP	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PITSS

Degron related mutations and impact score

Drug responses associated with MUC3A mutations

All proteins holding degron of PITSS