DegronMD

Uniprot ID: Q8TAM2

Source protein: Tetratricopeptide repeat protein 8

Source gene: TTC8

Class: DEG_SPOP_SBC_1

Location: 150:154

E3 ligase: SPOP

DEGRON score: 0.9945

ASA_SCORE: 53.36

COIL: 0.6346

CONS_SCORE: 0.4695

DSS_SCORE: 0.4757

HELIX: 0.3378

FCONS_SCORE: 0.985

RIG_SCORE: 0.7218

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R153W	SUP-T1	haematopoietic_and_lymphoid_tissue	COSMIC	PITSS	DEG_SPOP_SBC_1	0.8634
p.L151P	DO41434	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	0.7582
p.L155F	DO229035	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	0.75
p.T153M	DO13863	GBM	ICGC	PITSS	DEG_SPOP_SBC_1	0.7423
p.T144I	TCGA-FR-A3YN	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	0.6111
p.T163M	TCGA-19-5956	GBM	TCGA	PITSS	DEG_SPOP_SBC_1	0.5278
p.R149H	TCGA-AA-3864	COAD	TCGA	PITSS	DEG_SPOP_SBC_1	0.3056
p.V149A	SIDM00166	Other Solid Cancers	GDSC	PITSS	DEG_SPOP_SBC_1	0.3056
p.V149A	ACH-000302	Endometrial/Uterine Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.3056
p.G156R	NCI-H1693	lung	COSMIC	PITSS	DEG_SPOP_SBC_1	0.2778
p.L157F	DO232224	PBCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.25
p.T158A	DO52021	LUSC	ICGC	PITSS	DEG_SPOP_SBC_1	0.2222
p.G146V	DO27923	ORCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.2222
p.T158I	SIDM00557	Neuroblastoma	GDSC	PITSS	DEG_SPOP_SBC_1	0.2222
p.T158I	ACH-000345	Neuroblastoma	CCLE	PITSS	DEG_SPOP_SBC_1	0.2222
p.T158I	KP-N-RT-BM-1	autonomic_ganglia	COSMIC	PITSS	DEG_SPOP_SBC_1	0.2222
p.G146R	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	0.2222
p.G146R	ACH-000021	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.2222
p.G146R	ACH-000033	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.2222
p.G146R	NCI-H1693	lung	COSMIC	PITSS	DEG_SPOP_SBC_1	0.2222
p.A145T	U251	central_nervous_system	COSMIC	PITSS	DEG_SPOP_SBC_1	0.1944
p.L161P	TCGA-A5-A0GB	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	0.1389
p.R143S	TCGA-IB-7651	PAAD	TCGA	PITSS	DEG_SPOP_SBC_1	0.1389
p.D161N	SIDM00603	Head and Neck Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	0.1389
p.D161N	ACH-001543	Head and Neck Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.1389

Showing 1 to 25 of 27 entries

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Drug responses associated with TTC8 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of PITSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	74:78	PITSS	SPOP	0.5535	More...
P0C7T5	Ataxin-1-like	DEG_SPOP_SBC_1	459:463	PITSS	SPOP	0.9666	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	506:510	PITSS	SPOP	0.6301	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	258:262	PITSS	SPOP	0.9141	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1386:1390	PITSS	SPOP	0.7751	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	478:482	PITSS	SPOP	0.9764	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	1219:1223	PITSS	SPOP	0.9345	More...
Q52LA3	Protein lin-52 homolog	DEG_SPOP_SBC_1	49:53	PITSS	SPOP	0.9964	More...
Q8TAM2	Tetratricopeptide repeat protein 8	DEG_SPOP_SBC_1	150:154	PITSS	SPOP	0.9945	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_SPOP_SBC_1	1269:1273	PITSS	SPOP	0.9014	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PITSS

Degron related mutations and impact score

Drug responses associated with TTC8 mutations

All proteins holding degron of PITSS