DegronMD

Uniprot ID: P0C7T5

Source protein: Ataxin-1-like

Source gene: ATXN1L

Class: DEG_SPOP_SBC_1

Location: 459:463

E3 ligase: SPOP

DEGRON score: 0.9666

ASA_SCORE: 77.1

COIL: 0.8788

CONS_SCORE: 0.5554

DSS_SCORE: 0.6781

HELIX: 0.0652

FCONS_SCORE: 0.8781

RIG_SCORE: 0.6262

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T456M	TCGA-EO-A22U	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	0.6944
p.T456M	DO43755	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	0.6944
p.S463P	DO222737	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6752
p.H464Q	TCGA-B5-A1MX	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	0.3056
p.H464Q	DO41999	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	0.3056
p.P458S	ACH-000982	Colon/Colorectal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.3056
p.P458S	ACH-001345	Colon/Colorectal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.3056
p.L465F	DO229008	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	0.2778
p.E454Q	ACH-000975	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.1944

Showing 1 to 9 of 9 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	74:78	PITSS	SPOP	0.5535	More...
P0C7T5	Ataxin-1-like	DEG_SPOP_SBC_1	459:463	PITSS	SPOP	0.9666	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	506:510	PITSS	SPOP	0.6301	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	258:262	PITSS	SPOP	0.9141	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1386:1390	PITSS	SPOP	0.7751	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	478:482	PITSS	SPOP	0.9764	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	1219:1223	PITSS	SPOP	0.9345	More...
Q52LA3	Protein lin-52 homolog	DEG_SPOP_SBC_1	49:53	PITSS	SPOP	0.9964	More...
Q8TAM2	Tetratricopeptide repeat protein 8	DEG_SPOP_SBC_1	150:154	PITSS	SPOP	0.9945	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_SPOP_SBC_1	1269:1273	PITSS	SPOP	0.9014	More...

Showing 1 to 10 of 10 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons