DegronMD - P58397(ADAMTS12)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H65N	TCGA-33-4566	LUSC	TCGA	PITSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.0833
p.H65N	DO26790	LUSC	ICGC	PITSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.0833
p.T1123K	TCGA-34-8456	LUSC	TCGA	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation altering degron motif	0.7306
p.T1123K	DO219135	LUSC	ICGC	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation altering degron motif	0.7306
p.P1198H	TCGA-37-3792	LUSC	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation altering degron motif	0.7694
p.P1198H	DO27192	LUSC	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation altering degron motif	0.7694
p.S1115L	TCGA-60-2721	LUSC	TCGA	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.1944
p.S1115L	TCGA-GN-A266	SKCM	TCGA	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.1944
p.S1115L	SIDM00189	Melanoma	GDSC	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.1944
p.V1189M	TCGA-AP-A059	UCEC	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.0833
p.V1189M	DO41361	UCEC	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.0833
p.F66L	TCGA-B5-A0JY	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1111
p.F66L	DO43041	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1111
p.S1125I	TCGA-B5-A1MX	UCEC	TCGA	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.3056
p.P1212S	TCGA-B6-A0IE	BRCA	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.1389
p.P1212S	DO3055	BRCA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.1389
p.A1121T	TCGA-BR-7851	STAD	TCGA	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation altering degron motif	0.6028
p.A1121T	DO38711	STAD	ICGC	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation altering degron motif	0.6028
p.P1195S	TCGA-CZ-4853	KIRC	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.25
p.P1195S	DO16111	KIRC	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.25
p.T1114I	TCGA-DA-A3F8	SKCM	TCGA	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.1667
p.G86S	TCGA-DK-AA6U	BLCA	TCGA	PITSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1111
p.G86S	DO219008	BLCA	ICGC	PITSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1111
p.E1193Q	TCGA-E7-A3Y1	BLCA	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.1944
p.E1193Q	DO528	BLCA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.1944
p.S1191R	TCGA-EE-A29S	SKCM	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.1389
p.P1211S	TCGA-F5-6814	READ	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.1667
p.P1211S	DO36556	READ	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.1667
p.L1129M	TCGA-FJ-A3ZE	BLCA	TCGA	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.1944
p.L1129M	DO484	BLCA	ICGC	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.1944
p.M1194I	TCGA-J2-8194	LUAD	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.2222
p.M1194I	DO23971	LUAD	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.2222
p.G70S	TCGA-PK-A5HB	ACC	TCGA	PITSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.2222
p.S1132F	TCGA-YD-A9TA	SKCM	TCGA	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.1111
p.S1132F	DO219503	SKCM	ICGC	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.1111
p.S1196C	DO534	BLCA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.2778
p.E1133Q	DO528	BLCA	ICGC	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.0833
p.L1215I	DO7831	COAD	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.0556
p.L84V	DO233906	GACA	ICGC	PITSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1667
p.A1205E	DO229036	LICA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation altering degron motif	0.7701
p.E1211K	DO229050	LICA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.1667
p.P1212H	DO23256	LINC	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.1389
p.M1190I	DO23537	LIRI	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.1111
p.P74L	DO222843	MELA	ICGC	PITSS	DEG_SPOP_SBC_1	74:78	Mutation altering degron motif	0.7582
p.S1196F	DO232224	PBCA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation rewiring degron network	0.2778
p.T1201I	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation altering degron motif	0.7078
p.T1201I	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation altering degron motif	0.7078
p.T1201I	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation altering degron motif	0.7078
p.P1202R	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation altering degron motif	0.7512
p.P1202R	ACH-000837	Lung Cancer	CCLE	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation altering degron motif	0.7512
p.P1202R	NCI-H322M	lung	COSMIC	PPLTPDLS	DEG_SCF_FBW7_1	1198:1205	Mutation altering degron motif	0.7512
p.D85G	ACH-000982	Colon/Colorectal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	74:78	Mutation rewiring degron network	0.1389
p.M1132V	MDA-MB-231	breast	COSMIC	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.1111
p.P1117R	NCI-H322M	lung	COSMIC	VATTT	DEG_SPOP_SBC_1	1120:1124	Mutation rewiring degron network	0.25

Kaplan plot for ADAMTS12 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAMTS12

UniProt ID: P58397

Entrez ID: 81792

Protein name: A disintegrin and metalloproteinase with thrombospondin motifs 12 (ADAM-TS 12) (ADAM-TS12) (ADAMTS-12) (EC 3.4.24.-)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAMTS12 in