DegronMD

Uniprot ID: P58397

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 12

Source gene: ADAMTS12

Class: DEG_SPOP_SBC_1

Location: 1120:1124

E3 ligase: SPOP

DEGRON score: 0.8788

ASA_SCORE: 59.54

COIL: 0.381

CONS_SCORE: 0.3031

DSS_SCORE: 0.6335

HELIX: 0.0282

FCONS_SCORE: 1.0132

RIG_SCORE: 0.7075

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1123K	TCGA-34-8456	LUSC	TCGA	VATTT	DEG_SPOP_SBC_1	0.7306
p.T1123K	DO219135	LUSC	ICGC	VATTT	DEG_SPOP_SBC_1	0.7306
p.S1115L	TCGA-60-2721	LUSC	TCGA	VATTT	DEG_SPOP_SBC_1	0.1944
p.S1115L	TCGA-GN-A266	SKCM	TCGA	VATTT	DEG_SPOP_SBC_1	0.1944
p.S1115L	SIDM00189	Melanoma	GDSC	VATTT	DEG_SPOP_SBC_1	0.1944
p.S1125I	TCGA-B5-A1MX	UCEC	TCGA	VATTT	DEG_SPOP_SBC_1	0.3056
p.A1121T	TCGA-BR-7851	STAD	TCGA	VATTT	DEG_SPOP_SBC_1	0.6028
p.A1121T	DO38711	STAD	ICGC	VATTT	DEG_SPOP_SBC_1	0.6028
p.T1114I	TCGA-DA-A3F8	SKCM	TCGA	VATTT	DEG_SPOP_SBC_1	0.1667
p.L1129M	TCGA-FJ-A3ZE	BLCA	TCGA	VATTT	DEG_SPOP_SBC_1	0.1944
p.L1129M	DO484	BLCA	ICGC	VATTT	DEG_SPOP_SBC_1	0.1944
p.S1132F	TCGA-YD-A9TA	SKCM	TCGA	VATTT	DEG_SPOP_SBC_1	0.1111
p.S1132F	DO219503	SKCM	ICGC	VATTT	DEG_SPOP_SBC_1	0.1111
p.E1133Q	DO528	BLCA	ICGC	VATTT	DEG_SPOP_SBC_1	0.0833
p.M1132V	MDA-MB-231	breast	COSMIC	VATTT	DEG_SPOP_SBC_1	0.1111
p.P1117R	NCI-H322M	lung	COSMIC	VATTT	DEG_SPOP_SBC_1	0.25

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75821	Eukaryotic translation initiation factor 3 subunit G	DEG_SPOP_SBC_1	117:121	VATTT	SPOP	0.5185	More...
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	1120:1124	VATTT	SPOP	0.8788	More...
Q9H609	Zinc finger protein 576	DEG_SPOP_SBC_1	103:107	VATTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons