DegronMD

Uniprot ID: O75821

Source protein: Eukaryotic translation initiation factor 3 subunit G

Source gene: EIF3G

Class: DEG_SPOP_SBC_1

Location: 117:121

E3 ligase: SPOP

DEGRON score: 0.5185

ASA_SCORE: 58

COIL: 0.4446

CONS_SCORE: 0.447

DSS_SCORE: 0.5378

HELIX: 0.0296

FCONS_SCORE: 0.9489

RIG_SCORE: 0.7141

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P113H	TCGA-DK-A2I1	BLCA	TCGA	VATTT	DEG_SPOP_SBC_1	0.2222
p.P113H	DO444	BLCA	ICGC	VATTT	DEG_SPOP_SBC_1	0.2222
p.D111H	DO232065	ORCA	ICGC	VATTT	DEG_SPOP_SBC_1	0.1667
p.S108T	DO229245	THCA	ICGC	VATTT	DEG_SPOP_SBC_1	0.5278
p.D125A	SIDM00079	Ovarian Carcinoma	GDSC	VATTT	DEG_SPOP_SBC_1	0.2222
p.D125A	SK-OV-3	ovary	COSMIC	VATTT	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75821	Eukaryotic translation initiation factor 3 subunit G	DEG_SPOP_SBC_1	117:121	VATTT	SPOP	0.5185	More...
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	1120:1124	VATTT	SPOP	0.8788	More...
Q9H609	Zinc finger protein 576	DEG_SPOP_SBC_1	103:107	VATTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons