DegronMD

Uniprot ID: Q9H609

Source protein: Zinc finger protein 576

Source gene: ZNF576

Class: DEG_SPOP_SBC_1

Location: 103:107

E3 ligase: SPOP

DEGRON score: 0.9985

ASA_SCORE: 72.56

COIL: 0.8062

CONS_SCORE: 0.7026

DSS_SCORE: 0.4581

HELIX: 0.029

FCONS_SCORE: 0.8335

RIG_SCORE: 0.7187

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P102S	TCGA-AP-A1DK	UCEC	TCGA	VATTT	DEG_SPOP_SBC_1	0.3056
p.P102S	DO42033	UCEC	ICGC	VATTT	DEG_SPOP_SBC_1	0.3056
p.P102L	TCGA-B7-A5TI	STAD	TCGA	VATTT	DEG_SPOP_SBC_1	0.3056
p.P102L	DO222328	STAD	ICGC	VATTT	DEG_SPOP_SBC_1	0.3056
p.T106P	TCGA-EJ-7123	PRAD	TCGA	VATTT	DEG_SPOP_SBC_1	0.7031
p.T106P	DO36263	PRAD	ICGC	VATTT	DEG_SPOP_SBC_1	0.7031
p.P113H	TCGA-ER-A1A1	SKCM	TCGA	VATTT	DEG_SPOP_SBC_1	0.1667
p.P113H	DO37413	SKCM	ICGC	VATTT	DEG_SPOP_SBC_1	0.1667
p.C117F	TCGA-V5-AASW	ESCA	TCGA	VATTT	DEG_SPOP_SBC_1	0.0556
p.G94C	DO229041	LICA	ICGC	VATTT	DEG_SPOP_SBC_1	0.0833
p.A97S	DO229009	LICA	ICGC	VATTT	DEG_SPOP_SBC_1	0.1667
p.A96S	SIDM00690	Head and Neck Carcinoma	GDSC	VATTT	DEG_SPOP_SBC_1	0.1389
p.A96S	ACH-002251	Head and Neck Cancer	CCLE	VATTT	DEG_SPOP_SBC_1	0.1389
p.L101M	SIDM01619	Endometrial Carcinoma	GDSC	VATTT	DEG_SPOP_SBC_1	0.2778
p.L101M	ACH-000984	Endometrial/Uterine Cancer	CCLE	VATTT	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75821	Eukaryotic translation initiation factor 3 subunit G	DEG_SPOP_SBC_1	117:121	VATTT	SPOP	0.5185	More...
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	1120:1124	VATTT	SPOP	0.8788	More...
Q9H609	Zinc finger protein 576	DEG_SPOP_SBC_1	103:107	VATTT	SPOP	0.9985	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons