DegronMD

Uniprot ID: P58397

Source protein: A disintegrin and metalloproteinase with thrombospondin motifs 12

Source gene: ADAMTS12

Class: DEG_SCF_FBW7_1

Location: 1198:1205

E3 ligase: FBXW7

DEGRON score: 0.732

ASA_SCORE: 61.1625

COIL: 0.8309

CONS_SCORE: 0.2789

DSS_SCORE: 0.4919

HELIX: 0.0921

FCONS_SCORE: 0.9039

RIG_SCORE: 0.6932

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1198H	TCGA-37-3792	LUSC	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	0.7694
p.P1198H	DO27192	LUSC	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.7694
p.V1189M	TCGA-AP-A059	UCEC	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	0.0833
p.V1189M	DO41361	UCEC	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.0833
p.P1212S	TCGA-B6-A0IE	BRCA	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	0.1389
p.P1212S	DO3055	BRCA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.1389
p.P1195S	TCGA-CZ-4853	KIRC	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	0.25
p.P1195S	DO16111	KIRC	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.25
p.E1193Q	TCGA-E7-A3Y1	BLCA	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	0.1944
p.E1193Q	DO528	BLCA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.1944
p.S1191R	TCGA-EE-A29S	SKCM	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	0.1389
p.P1211S	TCGA-F5-6814	READ	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	0.1667
p.P1211S	DO36556	READ	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.1667
p.M1194I	TCGA-J2-8194	LUAD	TCGA	PPLTPDLS	DEG_SCF_FBW7_1	0.2222
p.M1194I	DO23971	LUAD	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.2222
p.S1196C	DO534	BLCA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.2778
p.L1215I	DO7831	COAD	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.0556
p.A1205E	DO229036	LICA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.7701
p.E1211K	DO229050	LICA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.1667
p.P1212H	DO23256	LINC	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.1389
p.M1190I	DO23537	LIRI	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.1111
p.S1196F	DO232224	PBCA	ICGC	PPLTPDLS	DEG_SCF_FBW7_1	0.2778
p.T1201I	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PPLTPDLS	DEG_SCF_FBW7_1	0.7078
p.T1201I	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	PPLTPDLS	DEG_SCF_FBW7_1	0.7078
p.T1201I	SIDM00431	T-Lymphoblastic Leukemia	GDSC	PPLTPDLS	DEG_SCF_FBW7_1	0.7078
p.P1202R	SIDM00117	Non-Small Cell Lung Carcinoma	GDSC	PPLTPDLS	DEG_SCF_FBW7_1	0.7512
p.P1202R	ACH-000837	Lung Cancer	CCLE	PPLTPDLS	DEG_SCF_FBW7_1	0.7512
p.P1202R	NCI-H322M	lung	COSMIC	PPLTPDLS	DEG_SCF_FBW7_1	0.7512

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPLTPDLS

Degron related mutations and impact score

Drug responses associated with ADAMTS12 mutations

All proteins holding degron of PPLTPDLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SCF_FBW7_1	1198:1205	PPLTPDLS	FBXW7	0.732	More...