DegronMD - Q8IXJ9(ASXL1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S441F	TCGA-18-3409	LUSC	TCGA	VPLYKD	LIG_APCC_ABBA_1	446:451	Mutation rewiring degron network	0.1944
p.C193Y	TCGA-2G-AAGI	TGCT	TCGA	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.0833
p.R411L	TCGA-4Z-AA7M	BLCA	TCGA	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.0833
p.R411L	SIDM01635	Glioblastoma	GDSC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.0833
p.R411L	ACH-000027	Brain Cancer	CCLE	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.0833
p.E1228K	TCGA-55-8092	LUAD	TCGA	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1944
p.E1228K	DO234174	ESAD	ICGC	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1944
p.E1228K	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1944
p.E1228K	ACH-000873	Esophageal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1944
p.E1228K	KYSE-270	oesophagus	COSMIC	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1944
p.A195T	TCGA-85-8481	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1389
p.A195T	DO45465	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1389
p.G197C	TCGA-85-8481	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1944
p.G197C	DO45465	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1944
p.D196N	TCGA-85-8666	LUSC	TCGA	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1667
p.D196N	DO45547	LUSC	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1667
p.D475N	TCGA-AP-A056	UCEC	TCGA	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2222
p.G587C	TCGA-AX-A2HC	UCEC	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1389
p.A459T	TCGA-AZ-6601	COAD	TCGA	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.1111
p.A459T	TCGA-AZ-6601	COAD	TCGA	VPLYKD	LIG_APCC_ABBA_1	446:451	Mutation rewiring degron network	0.1111
p.S1209N	TCGA-B5-A0JY	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation blocking phosphorylation signal	0.5
p.E1006K	TCGA-BH-A0B9	BRCA	TCGA	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.0833
p.D1004N	TCGA-BR-A4PE	STAD	TCGA	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.1389
p.S412F	TCGA-CK-4951	COAD	TCGA	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.0556
p.P570T	TCGA-CK-4951	COAD	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.2778
p.G197D	TCGA-D1-A1O7	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1944
p.G197D	DO41139	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1944
p.S207G	TCGA-D7-A6EY	STAD	TCGA	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.3056
p.S207G	TCGA-G4-6628	COAD	TCGA	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.3056
p.S207G	DO10132	COAD	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.3056
p.S207G	DO50118	STAD	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.3056
p.H407R	TCGA-D8-A1XQ	BRCA	TCGA	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.1944
p.H407R	DO3095	BRCA	ICGC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.1944
p.P840S	TCGA-DA-A1HV	SKCM	TCGA	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.3056
p.P567L	TCGA-EE-A181	SKCM	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1944
p.S203F	TCGA-EE-A2MR	SKCM	TCGA	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.6871
p.S203F	DO37819	SKCM	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.6871
p.A215T	TCGA-EO-A22T	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.0833
p.A215T	DO222955	BTCA	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.0833
p.A215T	DO42320	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.0833
p.D445G	TCGA-F5-6814	READ	TCGA	VPLYKD	LIG_APCC_ABBA_1	446:451	Mutation rewiring degron network	0.3056
p.P582H	TCGA-G4-6302	COAD	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.2778
p.E480K	TCGA-HD-7832	HNSC	TCGA	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.0833
p.I579F	TCGA-LN-A49P	ESCA	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation altering degron motif	0.7415
p.R573P	TCGA-O2-A5IB	LUSC	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation altering degron motif	0.7512
p.E1228Q	TCGA-SY-A9G5	BLCA	TCGA	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1944
p.R411C	TCGA-XK-AAIW	PRAD	TCGA	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.0833
p.E1223Q	DO51906	BLCA	ICGC	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation altering degron motif	0.6744
p.R406L	DO218976	BLCA	ICGC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.2222
p.E1001K	DO1459	BRCA	ICGC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.2222
p.D858H	DO1459	BRCA	ICGC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.0556
p.A454T	DO8119	COAD	ICGC	VPLYKD	LIG_APCC_ABBA_1	446:451	Mutation rewiring degron network	0.25
p.P565T	DO10582	COAD	ICGC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1389
p.S407F	DO10582	COAD	ICGC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.1944
p.P577H	DO8778	COAD	ICGC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation altering degron motif	0.7694
p.R402Q	DO233766	GACA	ICGC	IQRGPATR	SCF_FBXL2	395:402	Mutation altering degron motif	0.7329
p.E475K	DO16061	HNSC	ICGC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2222
p.G398C	DO228976	LICA	ICGC	IQRGPATR	SCF_FBXL2	395:402	Mutation altering degron motif	0.76
p.A449S	DO229026	LICA	ICGC	VPLYKD	LIG_APCC_ABBA_1	446:451	Mutation altering degron motif	0.7588
p.S458I	DO229031	LICA	ICGC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.0833
p.S458I	DO229031	LICA	ICGC	VPLYKD	LIG_APCC_ABBA_1	446:451	Mutation rewiring degron network	0.1389
p.C387F	DO229031	LICA	ICGC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.1111
p.E1223K	DO26220	LUAD	ICGC	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation altering degron motif	0.7022
p.E1223K	KYSE-270	oesophagus	COSMIC	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation altering degron motif	0.7022
p.R408L	DO224563	LUSC	ICGC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.1667
p.S436F	DO26444	LUSC	ICGC	VPLYKD	LIG_APCC_ABBA_1	446:451	Mutation rewiring degron network	0.0556
p.R568P	DO219227	LUSC	ICGC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation substituting flanking lysine	0.3333
p.T839P	DO228485	MALY	ICGC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.2778
p.S209F	DO222420	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.25
p.P202L	DO222662	MELA	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.7582
p.D999E	DO46366	OV	ICGC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.2778
p.R406C	DO51407	PRAD	ICGC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.2222
p.D440G	DO36556	READ	ICGC	VPLYKD	LIG_APCC_ABBA_1	446:451	Mutation substituting flanking lysine	0.2778
p.P835S	DO37659	SKCM	ICGC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.1667
p.P562L	DO37444	SKCM	ICGC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.0556
p.E479D	DO38423	STAD	ICGC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.1111
p.D999N	DO47773	STAD	ICGC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.2778
p.S204N	DO229211	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.7069
p.S205G	DO229245	THCA	ICGC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.6993
p.G582C	DO41572	UCEC	ICGC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.2778
p.R408Q	DO41235	UCEC	ICGC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.1667
p.D470N	DO43971	UCEC	ICGC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.6932
p.N986S	SIDM00376	B-Lymphoblastic Leukemia	GDSC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.1667
p.N986S	SIDM00848	Ewing's Sarcoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.1667
p.N986S	SIDM00259	Neuroblastoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.1667
p.N986S	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.1667
p.N986S	SIDM00123	Kidney Carcinoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.1667
p.N986S	SIDM00975	Melanoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.1667
p.N986S	SIDM01659	Kidney Carcinoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.1667
p.S206N	SIDM00946	T-Lymphoblastic Leukemia	GDSC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.7069
p.S206N	ACH-000981	Leukemia	CCLE	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.7069
p.S206N	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation altering degron motif	0.7069
p.V585A	SIDM00845	Burkitt's Lymphoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1944
p.V585A	SIDM01519	Head and Neck Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1944
p.V585A	ACH-000786	Lymphoma	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1944
p.V585A	Daudi	haematopoietic and lymphoid tissue	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1944
p.Q588R	SIDM00845	Burkitt's Lymphoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1111
p.Q588R	SIDM00461	Acute Myeloid Leukemia	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1111
p.Q588R	SIDM01519	Head and Neck Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1111
p.Q588R	ACH-000786	Lymphoma	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1111
p.Q588R	Daudi	haematopoietic and lymphoid tissue	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.1111
p.S846N	SIDM00198	Ewing's Sarcoma	GDSC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation altering degron motif	0.5958
p.S846N	ACH-002114	Bone Cancer	CCLE	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation altering degron motif	0.5958
p.S846N	EW-16	bone	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation altering degron motif	0.5958
p.G200D	SIDM00654	Small Cell Lung Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.2778
p.G200D	ACH-000866	Lung Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.2778
p.G200D	NCI-H1048	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.2778
p.K838R	SIDM00690	Head and Neck Carcinoma	GDSC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation substituting flanking lysine	0.3611
p.K838R	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation substituting flanking lysine	0.3611
p.K838R	SIDM01133	Other Solid Cancers	GDSC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation substituting flanking lysine	0.3611
p.K838R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation substituting flanking lysine	0.3611
p.K838R	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation substituting flanking lysine	0.3611
p.R394H	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.3056
p.R394H	BEN	lung	COSMIC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.3056
p.G406R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.2222
p.G406R	ACH-000929	Lung Cancer	CCLE	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.2222
p.G406R	NCI-H2110	lung	COSMIC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.2222
p.A473T	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2778
p.A473T	ACH-000929	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2778
p.A473T	NCI-H2110	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2778
p.E477Q	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.1667
p.D475Y	SIDM01124	Non-Small Cell Lung Carcinoma	GDSC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2222
p.D475Y	ACH-000945	Lung Cancer	CCLE	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2222
p.D475Y	NCI-H650	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation rewiring degron network	0.2222
p.K838N	SIDM01157	Other Solid Cancers	GDSC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation substituting flanking lysine	0.3611
p.K838N	ACH-001400	Cervical Cancer	CCLE	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation substituting flanking lysine	0.3611
p.K838N	SW954	vulva	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation substituting flanking lysine	0.3611
p.R573W	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation altering degron motif	0.8634
p.R573W	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation altering degron motif	0.8634
p.R573W	ACH-000784	Esophageal Cancer	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation altering degron motif	0.8634
p.R573W	ACH-000916	Lung Cancer	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation altering degron motif	0.8634
p.R573W	NCI-H1573	lung	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation altering degron motif	0.8634
p.R573W	KYSE-70	oesophagus	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation altering degron motif	0.8634
p.P853L	SIDM01159	Other Sarcomas	GDSC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.1944
p.P853L	SW872	soft tissue	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.1944
p.V584A	SIDM00217	Colorectal Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.2222
p.V584A	ACH-000999	Colon/Colorectal Cancer	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.2222
p.T711A	SIDM00534	Colorectal Carcinoma	GDSC	RREDLPSLR	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1667
p.T711A	ACH-000986	Colon/Colorectal Cancer	CCLE	RREDLPSLR	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1667
p.T711A	HT-115	large intestine	COSMIC	RREDLPSLR	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1667
p.P570L	SIDM01608	Endometrial Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.2778
p.P570L	ACH-000990	Endometrial/Uterine Cancer	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.2778
p.M1229V	SIDM01608	Endometrial Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1667
p.M1229V	ACH-000990	Endometrial/Uterine Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1667
p.L1213V	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1667
p.L1213V	ACH-000912	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1667
p.E1233K	SIDM01470	Acute Myeloid Leukemia	GDSC	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.0556
p.E1233K	ACH-000387	Leukemia	CCLE	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.0556
p.R734G	SIDM01588	Endometrial Carcinoma	GDSC	RREDLPSLR	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.R734G	ACH-000993	Endometrial/Uterine Cancer	CCLE	RREDLPSLR	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0833
p.A709V	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	RREDLPSLR	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1111
p.A709V	ACH-000777	Esophageal Cancer	CCLE	RREDLPSLR	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.1111
p.A735T	ACH-001518	Endometrial/Uterine Cancer	CCLE	RREDLPSLR	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0556
p.R1212H	SNU-61	large intestine	COSMIC	PITSS	DEG_SPOP_SBC_1	1219:1223	Mutation rewiring degron network	0.1389
p.R990C	COR-L321	NS	COSMIC	LSPHGE	LIG_APCC_ABBA_1	992:997	Mutation rewiring degron network	0.2778
p.P848L	SW872	soft tissue	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation altering degron motif	0.7582
p.K833N	SW954	vulva	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation rewiring degron network	0.1111
p.R389H	BEN	lung	COSMIC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.1667
p.A412T	NCI-H2110	lung	COSMIC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.0556
p.Q583R	Daudi	haematopoietic and lymphoid tissue	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.25
p.A468T	NCI-H2110	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.7139
p.R568W	KYSE-70	oesophagus	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation substituting flanking lysine	0.3333
p.R568W	NCI-H1573	lung	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation substituting flanking lysine	0.3333
p.R408W	COLO-320-HSR	large intestine	COSMIC	IQRGPATR	SCF_FBXL2	395:402	Mutation rewiring degron network	0.1667
p.V846A	CW-2	large intestine	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation altering degron motif	0.6936
p.G401R	NCI-H2110	lung	COSMIC	IQRGPATR	SCF_FBXL2	395:402	Mutation altering degron motif	0.7568
p.A216V	SNU-81	large intestine	COSMIC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.0556
p.L198I	NCI-H1573	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.2222
p.V563A	Daudi	haematopoietic and lymphoid tissue	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation rewiring degron network	0.0833
p.G195D	NCI-H1048	lung	COSMIC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation rewiring degron network	0.1389
p.S201N	DND-41	haematopoietic and lymphoid tissue	COSMIC	PSSSS	DEG_SPOP_SBC_1	202:206	Mutation blocking phosphorylation signal	0.75
p.D470Y	NCI-H650	lung	COSMIC	PGTSS	DEG_SPOP_SBC_1	467:471	Mutation altering degron motif	0.7325
p.W735C	HCT-15	large intestine	COSMIC	RREDLPSLR	DEG_APCC_DBOX_1	717:725	Mutation rewiring degron network	0.0556
p.V580A	Daudi	haematopoietic and lymphoid tissue	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	572:580	Mutation altering degron motif	0.6936
p.S841N	EW-16	bone	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	841:848	Mutation altering degron motif	0.7069

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASXL1

UniProt ID: Q8IXJ9

Entrez ID: 171023

Protein name: Polycomb group protein ASXL1 (Additional sex combs-like protein 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASXL1 in