DegronMD

Uniprot ID: Q8IXJ9

Source protein: Polycomb group protein ASXL1

Source gene: ASXL1

Class: DEG_APCC_DBOX_1

Location: 572:580

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6444

ASA_SCORE: 114.1333

COIL: 0.8944

CONS_SCORE: 0.347

DSS_SCORE: 0.4607

HELIX: 0.0449

FCONS_SCORE: 0.996

RIG_SCORE: 0.7822

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G587C	TCGA-AX-A2HC	UCEC	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	0.1389
p.P570T	TCGA-CK-4951	COAD	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	0.2778
p.P567L	TCGA-EE-A181	SKCM	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	0.1944
p.P582H	TCGA-G4-6302	COAD	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	0.2778
p.I579F	TCGA-LN-A49P	ESCA	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	0.7415
p.R573P	TCGA-O2-A5IB	LUSC	TCGA	IRIQLSRIK	DEG_APCC_DBOX_1	0.7512
p.P565T	DO10582	COAD	ICGC	IRIQLSRIK	DEG_APCC_DBOX_1	0.1389
p.P577H	DO8778	COAD	ICGC	IRIQLSRIK	DEG_APCC_DBOX_1	0.7694
p.R568P	DO219227	LUSC	ICGC	IRIQLSRIK	DEG_APCC_DBOX_1	0.3333
p.P562L	DO37444	SKCM	ICGC	IRIQLSRIK	DEG_APCC_DBOX_1	0.0556
p.G582C	DO41572	UCEC	ICGC	IRIQLSRIK	DEG_APCC_DBOX_1	0.2778
p.V585A	SIDM00845	Burkitt's Lymphoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	0.1944
p.V585A	SIDM01519	Head and Neck Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	0.1944
p.V585A	ACH-000786	Lymphoma	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	0.1944
p.V585A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	0.1944
p.Q588R	SIDM00845	Burkitt's Lymphoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	0.1111
p.Q588R	SIDM00461	Acute Myeloid Leukemia	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	0.1111
p.Q588R	SIDM01519	Head and Neck Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	0.1111
p.Q588R	ACH-000786	Lymphoma	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	0.1111
p.Q588R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	0.1111
p.R573W	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	0.8634
p.R573W	SIDM00749	Non-Small Cell Lung Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	0.8634
p.R573W	ACH-000784	Esophageal Cancer	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	0.8634
p.R573W	ACH-000916	Lung Cancer	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	0.8634
p.R573W	NCI-H1573	lung	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	0.8634
p.R573W	KYSE-70	oesophagus	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	0.8634
p.V584A	SIDM00217	Colorectal Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	0.2222
p.V584A	ACH-000999	Colon/Colorectal Cancer	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	0.2222
p.P570L	SIDM01608	Endometrial Carcinoma	GDSC	IRIQLSRIK	DEG_APCC_DBOX_1	0.2778
p.P570L	ACH-000990	Endometrial/Uterine Cancer	CCLE	IRIQLSRIK	DEG_APCC_DBOX_1	0.2778
p.Q583R	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	0.25
p.R568W	KYSE-70	oesophagus	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	0.3333
p.R568W	NCI-H1573	lung	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	0.3333
p.V563A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	0.0833
p.V580A	Daudi	haematopoietic_and_lymphoid_tissue	COSMIC	IRIQLSRIK	DEG_APCC_DBOX_1	0.6936

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: IRIQLSRIK

Degron related mutations and impact score

Drug responses associated with ASXL1 mutations

All proteins holding degron of IRIQLSRIK

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXJ9	Polycomb group protein ASXL1	DEG_APCC_DBOX_1	572:580	IRIQLSRIK	APC,CDC20,FZR1	0.6444	More...