DegronMD

Uniprot ID: Q8IXJ9

Source protein: Polycomb group protein ASXL1

Source gene: ASXL1

Class: LIG_APCC_ABBA_1

Location: 992:997

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.991

ASA_SCORE: 90.1

COIL: 0.9405

CONS_SCORE: 0.3422

DSS_SCORE: 0.6674

HELIX: 0.0265

FCONS_SCORE: 1.1784

RIG_SCORE: 0.5981

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1006K	TCGA-BH-A0B9	BRCA	TCGA	LSPHGE	LIG_APCC_ABBA_1	0.0833
p.D1004N	TCGA-BR-A4PE	STAD	TCGA	LSPHGE	LIG_APCC_ABBA_1	0.1389
p.E1001K	DO1459	BRCA	ICGC	LSPHGE	LIG_APCC_ABBA_1	0.2222
p.D999E	DO46366	OV	ICGC	LSPHGE	LIG_APCC_ABBA_1	0.2778
p.D999N	DO47773	STAD	ICGC	LSPHGE	LIG_APCC_ABBA_1	0.2778
p.N986S	SIDM00376	B-Lymphoblastic Leukemia	GDSC	LSPHGE	LIG_APCC_ABBA_1	0.1667
p.N986S	SIDM00848	Ewing's Sarcoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	0.1667
p.N986S	SIDM00259	Neuroblastoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	0.1667
p.N986S	SIDM00070	B-Cell Non-Hodgkin's Lymphoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	0.1667
p.N986S	SIDM00123	Kidney Carcinoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	0.1667
p.N986S	SIDM00975	Melanoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	0.1667
p.N986S	SIDM01659	Kidney Carcinoma	GDSC	LSPHGE	LIG_APCC_ABBA_1	0.1667
p.R990C	COR-L321	NS	COSMIC	LSPHGE	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXJ9	Polycomb group protein ASXL1	LIG_APCC_ABBA_1	992:997	LSPHGE	APC,CDC20,FZR1	0.991	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons