DegronMD

Uniprot ID: Q8IXJ9

Source protein: Polycomb group protein ASXL1

Source gene: ASXL1

Class: DEG_SCF_FBW7_1

Location: 841:848

E3 ligase: FBXW7

DEGRON score: 0.9959

ASA_SCORE: 94.425

COIL: 0.9656

CONS_SCORE: 0.3646

DSS_SCORE: 0.7379

HELIX: 0.0116

FCONS_SCORE: 1.3227

RIG_SCORE: 0.6133

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P840S	TCGA-DA-A1HV	SKCM	TCGA	VNVTPSST	DEG_SCF_FBW7_1	0.3056
p.D858H	DO1459	BRCA	ICGC	VNVTPSST	DEG_SCF_FBW7_1	0.0556
p.T839P	DO228485	MALY	ICGC	VNVTPSST	DEG_SCF_FBW7_1	0.2778
p.P835S	DO37659	SKCM	ICGC	VNVTPSST	DEG_SCF_FBW7_1	0.1667
p.S846N	SIDM00198	Ewing's Sarcoma	GDSC	VNVTPSST	DEG_SCF_FBW7_1	0.5958
p.S846N	ACH-002114	Bone Cancer	CCLE	VNVTPSST	DEG_SCF_FBW7_1	0.5958
p.S846N	EW-16	bone	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	0.5958
p.K838R	SIDM00690	Head and Neck Carcinoma	GDSC	VNVTPSST	DEG_SCF_FBW7_1	0.3611
p.K838R	SIDM00052	Esophageal Squamous Cell Carcinoma	GDSC	VNVTPSST	DEG_SCF_FBW7_1	0.3611
p.K838R	SIDM01133	Other Solid Cancers	GDSC	VNVTPSST	DEG_SCF_FBW7_1	0.3611
p.K838R	SIDM01072	Squamous Cell Lung Carcinoma	GDSC	VNVTPSST	DEG_SCF_FBW7_1	0.3611
p.K838R	SIDM00431	T-Lymphoblastic Leukemia	GDSC	VNVTPSST	DEG_SCF_FBW7_1	0.3611
p.K838N	SIDM01157	Other Solid Cancers	GDSC	VNVTPSST	DEG_SCF_FBW7_1	0.3611
p.K838N	ACH-001400	Cervical Cancer	CCLE	VNVTPSST	DEG_SCF_FBW7_1	0.3611
p.K838N	SW954	vulva	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	0.3611
p.P853L	SIDM01159	Other Sarcomas	GDSC	VNVTPSST	DEG_SCF_FBW7_1	0.1944
p.P853L	SW872	soft_tissue	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	0.1944
p.P848L	SW872	soft_tissue	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	0.7582
p.K833N	SW954	vulva	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	0.1111
p.V846A	CW-2	large_intestine	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	0.6936
p.S841N	EW-16	bone	COSMIC	VNVTPSST	DEG_SCF_FBW7_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXJ9	Polycomb group protein ASXL1	DEG_SCF_FBW7_1	841:848	VNVTPSST	FBXW7	0.9959	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons