DegronMD

Uniprot ID: Q8IXJ9

Source protein: Polycomb group protein ASXL1

Source gene: ASXL1

Class: DEG_SPOP_SBC_1

Location: 1219:1223

E3 ligase: SPOP

DEGRON score: 0.9345

ASA_SCORE: 84.28

COIL: 0.8988

CONS_SCORE: 0.3091

DSS_SCORE: 0.5644

HELIX: 0.072

FCONS_SCORE: 1.038

RIG_SCORE: 0.693

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E1228K	TCGA-55-8092	LUAD	TCGA	PITSS	DEG_SPOP_SBC_1	0.1944
p.E1228K	DO234174	ESAD	ICGC	PITSS	DEG_SPOP_SBC_1	0.1944
p.E1228K	SIDM01029	Esophageal Squamous Cell Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	0.1944
p.E1228K	ACH-000873	Esophageal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.1944
p.E1228K	KYSE-270	oesophagus	COSMIC	PITSS	DEG_SPOP_SBC_1	0.1944
p.S1209N	TCGA-B5-A0JY	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	0.5
p.E1228Q	TCGA-SY-A9G5	BLCA	TCGA	PITSS	DEG_SPOP_SBC_1	0.1944
p.E1223Q	DO51906	BLCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.6744
p.E1223K	DO26220	LUAD	ICGC	PITSS	DEG_SPOP_SBC_1	0.7022
p.E1223K	KYSE-270	oesophagus	COSMIC	PITSS	DEG_SPOP_SBC_1	0.7022
p.M1229V	SIDM01608	Endometrial Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	0.1667
p.M1229V	ACH-000990	Endometrial/Uterine Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.1667
p.L1213V	SIDM00017	Squamous Cell Lung Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	0.1667
p.L1213V	ACH-000912	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.1667
p.E1233K	SIDM01470	Acute Myeloid Leukemia	GDSC	PITSS	DEG_SPOP_SBC_1	0.0556
p.E1233K	ACH-000387	Leukemia	CCLE	PITSS	DEG_SPOP_SBC_1	0.0556
p.R1212H	SNU-61	large_intestine	COSMIC	PITSS	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C7T5	Ataxin-1-like	DEG_SPOP_SBC_1	459:463	PITSS	SPOP	0.9666	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	478:482	PITSS	SPOP	0.9764	More...
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	74:78	PITSS	SPOP	0.5535	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	258:262	PITSS	SPOP	0.9141	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1386:1390	PITSS	SPOP	0.7751	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_SPOP_SBC_1	1269:1273	PITSS	SPOP	0.9014	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	1219:1223	PITSS	SPOP	0.9345	More...
Q8TAM2	Tetratricopeptide repeat protein 8	DEG_SPOP_SBC_1	150:154	PITSS	SPOP	0.9945	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	506:510	PITSS	SPOP	0.6301	More...
Q52LA3	Protein lin-52 homolog	DEG_SPOP_SBC_1	49:53	PITSS	SPOP	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons