DegronMD - P0C7T5(ATXN1L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H464Q	TCGA-B5-A1MX	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.H464Q	DO41999	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.A265V	TCGA-DF-A2KU	UCEC	TCGA	PVLTPQES	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.1667
p.A265V	DO223286	UCEC	ICGC	PVLTPQES	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.1667
p.T456M	TCGA-EO-A22U	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	459:463	Mutation blocking phosphorylation signal	0.6944
p.T456M	DO43755	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	459:463	Mutation blocking phosphorylation signal	0.6944
p.L254I	DO222762	COCA	ICGC	PVLTPQES	DEG_SCF_FBW7_1	252:259	Mutation altering degron motif	0.6063
p.S463P	DO222737	COCA	ICGC	PITSS	DEG_SPOP_SBC_1	459:463	Mutation altering degron motif	0.6752
p.A265S	DO229045	LICA	ICGC	PVLTPQES	DEG_SCF_FBW7_1	252:259	Mutation rewiring degron network	0.1667
p.L465F	DO229008	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.2778
p.E454Q	ACH-000975	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.1944
p.P458S	ACH-000982	Colon/Colorectal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056
p.P458S	ACH-001345	Colon/Colorectal Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	459:463	Mutation rewiring degron network	0.3056

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons