DegronMD

Uniprot ID: P0C7T5

Source protein: Ataxin-1-like

Source gene: ATXN1L

Class: DEG_SCF_FBW7_1

Location: 252:259

E3 ligase: FBXW7

DEGRON score: 0.9746

ASA_SCORE: 91.7

COIL: 0.8648

CONS_SCORE: 0.5166

DSS_SCORE: 0.6479

HELIX: 0.0965

FCONS_SCORE: 1.03

RIG_SCORE: 0.6685

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A265V	TCGA-DF-A2KU	UCEC	TCGA	PVLTPQES	DEG_SCF_FBW7_1	0.1667
p.A265V	DO223286	UCEC	ICGC	PVLTPQES	DEG_SCF_FBW7_1	0.1667
p.L254I	DO222762	COCA	ICGC	PVLTPQES	DEG_SCF_FBW7_1	0.6063
p.A265S	DO229045	LICA	ICGC	PVLTPQES	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C7T5	Ataxin-1-like	DEG_SCF_FBW7_1	252:259	PVLTPQES	FBXW7	0.9746	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons