DegronMD - Q8TAM2(TTC8)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T163M	TCGA-19-5956	GBM	TCGA	PITSS	DEG_SPOP_SBC_1	150:154	Mutation blocking phosphorylation signal	0.5278
p.L161P	TCGA-A5-A0GB	UCEC	TCGA	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1389
p.R149H	TCGA-AA-3864	COAD	TCGA	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.3056
p.T144I	TCGA-FR-A3YN	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	150:154	Mutation blocking phosphorylation signal	0.6111
p.R143S	TCGA-IB-7651	PAAD	TCGA	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1389
p.F164L	DO9218	COAD	ICGC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.0556
p.T153M	DO13863	GBM	ICGC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7423
p.L155F	DO229035	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation blocking phosphorylation signal	0.75
p.T158A	DO52021	LUSC	ICGC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.G146V	DO27923	ORCA	ICGC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.L157F	DO232224	PBCA	ICGC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.25
p.L151P	DO41434	UCEC	ICGC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.7582
p.T158I	SIDM00557	Neuroblastoma	GDSC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.T158I	ACH-000345	Neuroblastoma	CCLE	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.T158I	KP-N-RT-BM-1	autonomic ganglia	COSMIC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.G146R	SIDM00742	Non-Small Cell Lung Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.G146R	ACH-000021	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.G146R	ACH-000033	Lung Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.G146R	NCI-H1693	lung	COSMIC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2222
p.D161N	SIDM00603	Head and Neck Carcinoma	GDSC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1389
p.D161N	ACH-001543	Head and Neck Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1389
p.D161N	KOSC-2	upper aerodigestive tract	COSMIC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1389
p.V149A	SIDM00166	Other Solid Cancers	GDSC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.3056
p.V149A	ACH-000302	Endometrial/Uterine Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.3056
p.G156R	NCI-H1693	lung	COSMIC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.2778
p.R153W	SUP-T1	haematopoietic and lymphoid tissue	COSMIC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation altering degron motif	0.8634
p.A145T	U251	central nervous system	COSMIC	PITSS	DEG_SPOP_SBC_1	150:154	Mutation rewiring degron network	0.1944

Kaplan plot for TTC8 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TTC8

UniProt ID: Q8TAM2

Entrez ID: 123016

Protein name: Tetratricopeptide repeat protein 8 (TPR repeat protein 8) (Bardet-Biedl syndrome 8 protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TTC8 in