DegronMD

Uniprot ID: P49790

Source protein: Nuclear pore complex protein Nup153

Source gene: NUP153

Class: DEG_SPOP_SBC_1

Location: 478:482

E3 ligase: SPOP

DEGRON score: 0.9764

ASA_SCORE: 79.14

COIL: 0.8838

CONS_SCORE: 0.432

DSS_SCORE: 0.3102

HELIX: 0.038

FCONS_SCORE: 0.7634

RIG_SCORE: 0.7171

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P492S	TCGA-CV-5439	HNSC	TCGA	PITSS	DEG_SPOP_SBC_1	0.0556
p.P492S	DO14200	HNSC	ICGC	PITSS	DEG_SPOP_SBC_1	0.0556
p.S491F	TCGA-ER-A19P	SKCM	TCGA	PITSS	DEG_SPOP_SBC_1	0.0833
p.S491F	DO47623	SKCM	ICGC	PITSS	DEG_SPOP_SBC_1	0.0833
p.K474N	TCGA-NK-A5D1	LUSC	TCGA	PITSS	DEG_SPOP_SBC_1	0.3333
p.K474N	DO219213	LUSC	ICGC	PITSS	DEG_SPOP_SBC_1	0.3333
p.L475R	DO44097	BLCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.25
p.P489S	DO233746	GACA	ICGC	PITSS	DEG_SPOP_SBC_1	0.1389
p.P478T	DO229009	LICA	ICGC	PITSS	DEG_SPOP_SBC_1	0.7031
p.G468A	DO45265	LIRI	ICGC	PITSS	DEG_SPOP_SBC_1	0.0556
p.P486S	DO220856	MELA	ICGC	PITSS	DEG_SPOP_SBC_1	0.2222
p.A481T	DO48915	PBCA	ICGC	PITSS	DEG_SPOP_SBC_1	0.7139
p.K474E	ACH-001610	Brain Cancer	CCLE	PITSS	DEG_SPOP_SBC_1	0.3333
p.P485L	NCI-H1573	lung	COSMIC	PITSS	DEG_SPOP_SBC_1	0.25
p.S481N	MHH-ES-1	bone	COSMIC	PITSS	DEG_SPOP_SBC_1	0.7069

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P0C7T5	Ataxin-1-like	DEG_SPOP_SBC_1	459:463	PITSS	SPOP	0.9666	More...
P49790	Nuclear pore complex protein Nup153	DEG_SPOP_SBC_1	478:482	PITSS	SPOP	0.9764	More...
P58397	A disintegrin and metalloproteinase with thrombospondin motifs 12	DEG_SPOP_SBC_1	74:78	PITSS	SPOP	0.5535	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	258:262	PITSS	SPOP	0.9141	More...
Q02505	Mucin-3A	DEG_SPOP_SBC_1	1386:1390	PITSS	SPOP	0.7751	More...
Q6EMB2	Tubulin polyglutamylase TTLL5	DEG_SPOP_SBC_1	1269:1273	PITSS	SPOP	0.9014	More...
Q8IXJ9	Polycomb group protein ASXL1	DEG_SPOP_SBC_1	1219:1223	PITSS	SPOP	0.9345	More...
Q8TAM2	Tetratricopeptide repeat protein 8	DEG_SPOP_SBC_1	150:154	PITSS	SPOP	0.9945	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	506:510	PITSS	SPOP	0.6301	More...
Q52LA3	Protein lin-52 homolog	DEG_SPOP_SBC_1	49:53	PITSS	SPOP	0.9964	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons