DegronMD

Uniprot ID: Q8IXJ9

Source protein: Polycomb group protein ASXL1

Source gene: ASXL1

Class: LIG_APCC_ABBA_1

Location: 446:451

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7547

ASA_SCORE: 99.45

COIL: 0.9068

CONS_SCORE: 0.309

DSS_SCORE: 0.5515

HELIX: 0.0377

FCONS_SCORE: 1.1139

RIG_SCORE: 0.7315

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S441F	TCGA-18-3409	LUSC	TCGA	VPLYKD	LIG_APCC_ABBA_1	0.1944
p.A459T	TCGA-AZ-6601	COAD	TCGA	VPLYKD	LIG_APCC_ABBA_1	0.1111
p.D445G	TCGA-F5-6814	READ	TCGA	VPLYKD	LIG_APCC_ABBA_1	0.3056
p.A454T	DO8119	COAD	ICGC	VPLYKD	LIG_APCC_ABBA_1	0.25
p.A449S	DO229026	LICA	ICGC	VPLYKD	LIG_APCC_ABBA_1	0.7588
p.S458I	DO229031	LICA	ICGC	VPLYKD	LIG_APCC_ABBA_1	0.1389
p.S436F	DO26444	LUSC	ICGC	VPLYKD	LIG_APCC_ABBA_1	0.0556
p.D440G	DO36556	READ	ICGC	VPLYKD	LIG_APCC_ABBA_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXJ9	Polycomb group protein ASXL1	LIG_APCC_ABBA_1	446:451	VPLYKD	APC,CDC20,FZR1	0.7547	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons