DegronMD

Uniprot ID: Q8IXJ9

Source protein: Polycomb group protein ASXL1

Source gene: ASXL1

Class: DEG_APCC_DBOX_1

Location: 717:725

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.886

ASA_SCORE: 110.1667

COIL: 0.8221

CONS_SCORE: 0.2644

DSS_SCORE: 0.5528

HELIX: 0.1452

FCONS_SCORE: 0.9995

RIG_SCORE: 0.7328

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T711A	SIDM00534	Colorectal Carcinoma	GDSC	RREDLPSLR	DEG_APCC_DBOX_1	0.1667
p.T711A	ACH-000986	Colon/Colorectal Cancer	CCLE	RREDLPSLR	DEG_APCC_DBOX_1	0.1667
p.T711A	HT-115	large_intestine	COSMIC	RREDLPSLR	DEG_APCC_DBOX_1	0.1667
p.R734G	SIDM01588	Endometrial Carcinoma	GDSC	RREDLPSLR	DEG_APCC_DBOX_1	0.0833
p.R734G	ACH-000993	Endometrial/Uterine Cancer	CCLE	RREDLPSLR	DEG_APCC_DBOX_1	0.0833
p.A709V	SIDM00015	Esophageal Squamous Cell Carcinoma	GDSC	RREDLPSLR	DEG_APCC_DBOX_1	0.1111
p.A709V	ACH-000777	Esophageal Cancer	CCLE	RREDLPSLR	DEG_APCC_DBOX_1	0.1111
p.A735T	ACH-001518	Endometrial/Uterine Cancer	CCLE	RREDLPSLR	DEG_APCC_DBOX_1	0.0556
p.W735C	HCT-15	large_intestine	COSMIC	RREDLPSLR	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXJ9	Polycomb group protein ASXL1	DEG_APCC_DBOX_1	717:725	RREDLPSLR	APC,CDC20,FZR1	0.886	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons