DegronMD

Uniprot ID: Q8IXJ9

Source protein: Polycomb group protein ASXL1

Source gene: ASXL1

Class: SCF_FBXL2

Location: 395:402

E3 ligase: FBXL2

DEGRON score: 0.9758

ASA_SCORE: 102.1875

COIL: 0.9375

CONS_SCORE: 0.2815

DSS_SCORE: 0.6407

HELIX: 0.0245

FCONS_SCORE: 1.015

RIG_SCORE: 0.6637

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R411L	TCGA-4Z-AA7M	BLCA	TCGA	IQRGPATR	SCF_FBXL2	0.0833
p.R411L	SIDM01635	Glioblastoma	GDSC	IQRGPATR	SCF_FBXL2	0.0833
p.R411L	ACH-000027	Brain Cancer	CCLE	IQRGPATR	SCF_FBXL2	0.0833
p.S412F	TCGA-CK-4951	COAD	TCGA	IQRGPATR	SCF_FBXL2	0.0556
p.H407R	TCGA-D8-A1XQ	BRCA	TCGA	IQRGPATR	SCF_FBXL2	0.1944
p.H407R	DO3095	BRCA	ICGC	IQRGPATR	SCF_FBXL2	0.1944
p.R411C	TCGA-XK-AAIW	PRAD	TCGA	IQRGPATR	SCF_FBXL2	0.0833
p.R406L	DO218976	BLCA	ICGC	IQRGPATR	SCF_FBXL2	0.2222
p.S407F	DO10582	COAD	ICGC	IQRGPATR	SCF_FBXL2	0.1944
p.R402Q	DO233766	GACA	ICGC	IQRGPATR	SCF_FBXL2	0.7329
p.G398C	DO228976	LICA	ICGC	IQRGPATR	SCF_FBXL2	0.76
p.C387F	DO229031	LICA	ICGC	IQRGPATR	SCF_FBXL2	0.1111
p.R408L	DO224563	LUSC	ICGC	IQRGPATR	SCF_FBXL2	0.1667
p.R406C	DO51407	PRAD	ICGC	IQRGPATR	SCF_FBXL2	0.2222
p.R408Q	DO41235	UCEC	ICGC	IQRGPATR	SCF_FBXL2	0.1667
p.R394H	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	IQRGPATR	SCF_FBXL2	0.3056
p.R394H	BEN	lung	COSMIC	IQRGPATR	SCF_FBXL2	0.3056
p.G406R	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	IQRGPATR	SCF_FBXL2	0.2222
p.G406R	ACH-000929	Lung Cancer	CCLE	IQRGPATR	SCF_FBXL2	0.2222
p.G406R	NCI-H2110	lung	COSMIC	IQRGPATR	SCF_FBXL2	0.2222
p.R389H	BEN	lung	COSMIC	IQRGPATR	SCF_FBXL2	0.1667
p.A412T	NCI-H2110	lung	COSMIC	IQRGPATR	SCF_FBXL2	0.0556
p.R408W	COLO-320-HSR	large_intestine	COSMIC	IQRGPATR	SCF_FBXL2	0.1667
p.G401R	NCI-H2110	lung	COSMIC	IQRGPATR	SCF_FBXL2	0.7568

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IXJ9	Polycomb group protein ASXL1	SCF_FBXL2	395:402	IQRGPATR	FBXL2	0.9758	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons