DegronMD

Uniprot ID: Q9H0E3

Source protein: Histone deacetylase complex subunit SAP130

Source gene: SAP130

Class: DEG_SIAH_1

Location: 428:436

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9939

ASA_SCORE: 102.0111

COIL: 0.9557

CONS_SCORE: 0.4536

DSS_SCORE: 0.4673

HELIX: 0.0153

FCONS_SCORE: 0.9842

RIG_SCORE: 0.7745

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R418W	DO48444	BLCA	ICGC	IPVAKVVPQ	DEG_SIAH_1	0.0556
p.R418W	ACH-000432	Leukemia	CCLE	IPVAKVVPQ	DEG_SIAH_1	0.0556
p.R418W	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	IPVAKVVPQ	DEG_SIAH_1	0.0556
p.P432T	DO456	BLCA	ICGC	IPVAKVVPQ	DEG_SIAH_1	0.7031
p.I433N	DO222616	ESCA	ICGC	IPVAKVVPQ	DEG_SIAH_1	0.728
p.H436N	DO229026	LICA	ICGC	IPVAKVVPQ	DEG_SIAH_1	0.7423
p.A444T	DO52026	LUSC	ICGC	IPVAKVVPQ	DEG_SIAH_1	0.1111
p.A444T	ACH-000999	Colon/Colorectal Cancer	CCLE	IPVAKVVPQ	DEG_SIAH_1	0.1111
p.A444T	SNU-1040	large_intestine	COSMIC	IPVAKVVPQ	DEG_SIAH_1	0.1111
p.P440L	DO222702	MELA	ICGC	IPVAKVVPQ	DEG_SIAH_1	0.2222
p.P432S	DO37819	SKCM	ICGC	IPVAKVVPQ	DEG_SIAH_1	0.6752
p.S434F	DO37406	SKCM	ICGC	IPVAKVVPQ	DEG_SIAH_1	0.7982
p.R444W	SIDM00962	Chronic Myelogenous Leukemia	GDSC	IPVAKVVPQ	DEG_SIAH_1	0.1111
p.R444W	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	IPVAKVVPQ	DEG_SIAH_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SIAH_1	428:436	IPVAKVVPQ	SIAH1,SIAH2,SIAH3	0.9939	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons