DegronMD

Uniprot ID: Q9H0E3

Source protein: Histone deacetylase complex subunit SAP130

Source gene: SAP130

Class: DEG_SPOP_SBC_1

Location: 302:306

E3 ligase: SPOP

DEGRON score: 0.7

ASA_SCORE: 89.04

COIL: 0.868

CONS_SCORE: 0.4795

DSS_SCORE: 0.4823

HELIX: 0.017

FCONS_SCORE: 1.0787

RIG_SCORE: 0.7677

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T305M	TCGA-46-3768	LUSC	TCGA	VITTT	DEG_SPOP_SBC_1	0.7423
p.T305M	TCGA-BR-6452	STAD	TCGA	VITTT	DEG_SPOP_SBC_1	0.7423
p.T305M	TCGA-T2-A6WZ	HNSC	TCGA	VITTT	DEG_SPOP_SBC_1	0.7423
p.T305M	DO219067	HNSC	ICGC	VITTT	DEG_SPOP_SBC_1	0.7423
p.T305M	DO26466	LUSC	ICGC	VITTT	DEG_SPOP_SBC_1	0.7423
p.T305M	DO38404	STAD	ICGC	VITTT	DEG_SPOP_SBC_1	0.7423
p.A307V	TCGA-DU-6392	LGG	TCGA	VITTT	DEG_SPOP_SBC_1	0.3056
p.A307V	SIDM00999	Bladder Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	0.3056
p.A307V	639-V	urinary_tract	COSMIC	VITTT	DEG_SPOP_SBC_1	0.3056
p.R308C	DO10132	COAD	ICGC	VITTT	DEG_SPOP_SBC_1	0.2778
p.R313Q	DO227996	COCA	ICGC	VITTT	DEG_SPOP_SBC_1	0.1389
p.R308H	DO222765	COCA	ICGC	VITTT	DEG_SPOP_SBC_1	0.2778
p.P292T	DO228971	LICA	ICGC	VITTT	DEG_SPOP_SBC_1	0.0556
p.I304V	DO50846	LICA	ICGC	VITTT	DEG_SPOP_SBC_1	0.7076
p.I304V	DO23248	LINC	ICGC	VITTT	DEG_SPOP_SBC_1	0.7076
p.D314H	DO41349	UCEC	ICGC	VITTT	DEG_SPOP_SBC_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75603	Chorion-specific transcription factor GCMb	DEG_SPOP_SBC_1	382:386	VITTT	SPOP	0.7442	More...
P17275	Transcription factor JunB	DEG_SPOP_SBC_1	98:102	VITTT	SPOP	0.9993	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	5155:5159	VITTT	SPOP	0.9393	More...
Q9H334	Forkhead box protein P1	DEG_SPOP_SBC_1	423:427	VITTT	SPOP	0.9878	More...
Q9H0E3	Histone deacetylase complex subunit SAP130	DEG_SPOP_SBC_1	302:306	VITTT	SPOP	0.7	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons