DegronMD - O75603(GCM2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P427T	TCGA-64-1679	LUAD	TCGA	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation altering degron motif	0.5919
p.P427T	DO26200	LUAD	ICGC	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation altering degron motif	0.5919
p.S390Y	TCGA-A5-A0GW	UCEC	TCGA	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.2222
p.S390Y	DO41103	UCEC	ICGC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.2222
p.V382M	TCGA-AR-A0TQ	BRCA	TCGA	VITTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7208
p.V382M	DO1623	BRCA	ICGC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7208
p.N415T	TCGA-AX-A2HD	UCEC	TCGA	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1111
p.N415T	DO42608	UCEC	ICGC	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1111
p.P427A	TCGA-BH-A0WA	BRCA	TCGA	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation altering degron motif	0.6392
p.P427A	DO2897	BRCA	ICGC	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation altering degron motif	0.6392
p.P433S	TCGA-EB-A553	SKCM	TCGA	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1944
p.P433S	DO47329	SKCM	ICGC	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1944
p.T381I	TCGA-EE-A2GC	SKCM	TCGA	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.3056
p.T381I	DO218906	SKCA	ICGC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.3056
p.T381I	DO37839	SKCM	ICGC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.3056
p.P429L	TCGA-EE-A2MU	SKCM	TCGA	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.3056
p.P429L	TCGA-W3-A824	SKCM	TCGA	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.3056
p.P429L	DO37436	SKCM	ICGC	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.3056
p.P429L	DO51271	SKCM	ICGC	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.3056
p.P433R	TCGA-EE-A3JD	SKCM	TCGA	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1944
p.P433R	DO50299	SKCM	ICGC	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1944
p.P432S	TCGA-FS-A1ZA	SKCM	TCGA	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.2222
p.P432S	DO37551	SKCM	ICGC	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.2222
p.T386I	DO233109	GACA	ICGC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7078
p.G422E	DO220886	MELA	ICGC	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.3056
p.P372L	DO220907	MELA	ICGC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.0556
p.P396F	DO222843	MELA	ICGC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.0556
p.T384A	SIDM01090	Colorectal Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.T384A	ACH-000943	Colon/Colorectal Cancer	CCLE	VITTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.T384A	RKO	large intestine	COSMIC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation altering degron motif	0.7139
p.P377L	SIDM00578	Neuroblastoma	GDSC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.1944
p.P377L	ACH-000804	Neuroblastoma	CCLE	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.1944
p.P377L	NB1	autonomic ganglia	COSMIC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.1944
p.A378T	SIDM01609	Endometrial Carcinoma	GDSC	VITTT	DEG_SPOP_SBC_1	382:386	Mutation rewiring degron network	0.2222
p.N415S	SIDM01559	Melanoma	GDSC	MSVYPE	LIG_APCC_ABBA_1	423:428	Mutation rewiring degron network	0.1111

Kaplan plot for GCM2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GCM2

UniProt ID: O75603

Entrez ID: 9247

Protein name: Chorion-specific transcription factor GCMb (hGCMb) (GCM motif protein 2) (Glial cells missing homolog 2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GCM2 in