DegronMD

Uniprot ID: O75603

Source protein: Chorion-specific transcription factor GCMb

Source gene: GCM2

Class: LIG_APCC_ABBA_1

Location: 423:428

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.943

ASA_SCORE: 59.9167

COIL: 0.7415

CONS_SCORE: 0.4542

DSS_SCORE: 0.4701

HELIX: 0.1102

FCONS_SCORE: 1.1311

RIG_SCORE: 0.6898

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P427T	TCGA-64-1679	LUAD	TCGA	MSVYPE	LIG_APCC_ABBA_1	0.5919
p.P427T	DO26200	LUAD	ICGC	MSVYPE	LIG_APCC_ABBA_1	0.5919
p.N415T	TCGA-AX-A2HD	UCEC	TCGA	MSVYPE	LIG_APCC_ABBA_1	0.1111
p.N415T	DO42608	UCEC	ICGC	MSVYPE	LIG_APCC_ABBA_1	0.1111
p.P427A	TCGA-BH-A0WA	BRCA	TCGA	MSVYPE	LIG_APCC_ABBA_1	0.6392
p.P427A	DO2897	BRCA	ICGC	MSVYPE	LIG_APCC_ABBA_1	0.6392
p.P433S	TCGA-EB-A553	SKCM	TCGA	MSVYPE	LIG_APCC_ABBA_1	0.1944
p.P433S	DO47329	SKCM	ICGC	MSVYPE	LIG_APCC_ABBA_1	0.1944
p.P429L	TCGA-EE-A2MU	SKCM	TCGA	MSVYPE	LIG_APCC_ABBA_1	0.3056
p.P429L	TCGA-W3-A824	SKCM	TCGA	MSVYPE	LIG_APCC_ABBA_1	0.3056
p.P429L	DO37436	SKCM	ICGC	MSVYPE	LIG_APCC_ABBA_1	0.3056
p.P429L	DO51271	SKCM	ICGC	MSVYPE	LIG_APCC_ABBA_1	0.3056
p.P433R	TCGA-EE-A3JD	SKCM	TCGA	MSVYPE	LIG_APCC_ABBA_1	0.1944
p.P433R	DO50299	SKCM	ICGC	MSVYPE	LIG_APCC_ABBA_1	0.1944
p.P432S	TCGA-FS-A1ZA	SKCM	TCGA	MSVYPE	LIG_APCC_ABBA_1	0.2222
p.P432S	DO37551	SKCM	ICGC	MSVYPE	LIG_APCC_ABBA_1	0.2222
p.G422E	DO220886	MELA	ICGC	MSVYPE	LIG_APCC_ABBA_1	0.3056
p.N415S	SIDM01559	Melanoma	GDSC	MSVYPE	LIG_APCC_ABBA_1	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O75603	Chorion-specific transcription factor GCMb	LIG_APCC_ABBA_1	423:428	MSVYPE	APC,CDC20,FZR1	0.943	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons